Adenomatous polyposis coli

APC
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1DEB, 1EMU, 1JPP, 1M5I, 1T08, 1TH1, 1V18, 2RQU, 3AU3, 3NMW, 3NMX, 3NMZ, 3QHE, 3RL7, 3RL8, 3T7U, 4G69, 4YJL, 4YK6, 4YJE
Identifiers
Aliases	APC, BTPS2, DP2, DP2.5, DP3, GS, PPP1R46, adenomatous polyposis coli, WNT signaling pathway regulator, Genes
External IDs	OMIM: 611731; MGI: 88039; HomoloGene: 30950; GeneCards: APC; OMA:APC - orthologs
Gene location (Mouse) Chr. Chromosome 18 (mouse)[1] Band 18 B1|18 18.53 cM Start 34,220,924 bp[1] End 34,322,552 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) n/a Top expressed in olfactory bulb substantia nigra lateral geniculate nucleus pontine nuclei medial dorsal nucleus subiculum medial geniculate nucleus anterior horn of spinal cord genital tubercle tail of embryo BioGPS More reference expression data
Gene ontology Molecular function gamma-catenin binding protein kinase binding microtubule plus-end binding microtubule binding cadherin binding protein kinase regulator activity protein binding beta-catenin binding ubiquitin protein ligase binding identical protein binding dynein complex binding Cellular component cytoskeleton adherens junction beta-catenin destruction complex nucleoplasm cytoplasm cell projection cytosol catenin complex cell junction nucleus lamellipodium membrane Wnt signalosome centrosome kinetochore bicellular tight junction ruffle membrane plasma membrane lateral plasma membrane perinuclear region of cytoplasm microtubule cytoplasmic microtubule Biological process negative regulation of cell population proliferation negative regulation of cyclin-dependent protein serine/threonine kinase activity mitotic spindle assembly checkpoint signaling positive regulation of cell migration positive regulation of protein catabolic process bicellular tight junction assembly regulation of microtubule-based process positive regulation of pseudopodium assembly regulation of attachment of spindle microtubules to kinetochore cellular response to DNA damage stimulus negative regulation of Wnt signaling pathway cell adhesion mitotic cytokinesis negative regulation of microtubule depolymerization positive regulation of apoptotic process canonical Wnt signaling pathway cell migration beta-catenin destruction complex assembly beta-catenin destruction complex disassembly negative regulation of canonical Wnt signaling pathway Wnt signaling pathway protein deubiquitination insulin receptor signaling pathway positive regulation of cell death protein homooligomerization positive regulation of protein localization to centrosome protein-containing complex assembly cell fate specification pattern specification process regulation of cell differentiation positive regulation of cold-induced thermogenesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 324 11789 Ensembl ENSG00000134982 ENSMUSG00000005871 UniProt P25054 Q61315 RefSeq (mRNA) NM_001127511 NM_000038 NM_001127510 NM_007462 NM_001360979 NM_001360980 RefSeq (protein) NP_000029 NP_001120982 NP_001120983 NP_001341824 NP_001341825 NP_001341826 NP_001341827 NP_001341828 NP_001341829 NP_001341830 NP_001341831 NP_001341832 NP_001341833 NP_001341834 NP_001341835 n/a Location (UCSC) n/a Chr 18: 34.22 – 34.32 Mb PubMed search [2] [3]
Wikidata
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Adenomatous polyposis coli (APC) also known as deleted in polyposis 2.5 (DP2.5) is a protein that in humans is encoded by the APC gene.^[4] The APC protein is a negative regulator that controls beta-catenin concentrations and interacts with E-cadherin, which are involved in cell adhesion. Mutations in the APC gene may result in colorectal cancer and desmoid tumors.^[5][6]

APC is classified as a tumor suppressor gene. Tumor suppressor genes prevent the uncontrolled growth of cells that may result in cancerous tumors. The protein made by the APC gene plays a critical role in several cellular processes that determine whether a cell may develop into a tumor. The APC protein helps control how often a cell divides, how it attaches to other cells within a tissue, how the cell polarizes and the morphogenesis of the 3D structures,^[7] or whether a cell moves within or away from tissue. This protein also helps ensure that the chromosome number in cells produced through cell division is correct. The APC protein accomplishes these tasks mainly through association with other proteins, especially those that are involved in cell attachment and signaling. The activity of one protein in particular, beta-catenin, is controlled by the APC protein (see: Wnt signaling pathway). Regulation of beta-catenin prevents genes that stimulate cell division from being turned on too often and prevents cell overgrowth.

The human APC gene is located on the long (q) arm of chromosome 5 in band q22.2 (5q22.2). The APC gene has been shown to contain an internal ribosome entry site. APC orthologs^[8] have also been identified in all mammals for which complete genome data are available.