Adenosine deaminase

ADA
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3IAR
Identifiers
Aliases	ADA, entrez:100, Adenosine deaminase, ADA1
External IDs	OMIM: 608958; MGI: 87916; HomoloGene: 37249; GeneCards: ADA; OMA:ADA - orthologs
Gene location (Human) Chr. Chromosome 20 (human)[1] Band 20q13.12 Start 44,584,896 bp[1] End 44,652,252 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2 84.44 cM|2 H3 Start 163,568,504 bp[2] End 163,592,159 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in jejunal mucosa duodenum thymus granulocyte body of stomach oocyte secondary oocyte right auricle apex of heart gastric mucosa Top expressed in decidua duodenum esophagus superior surface of tongue jejunum gastrula intestinal villus thymus zygote endothelial cell of lymphatic vessel More reference expression data BioGPS More reference expression data
Gene ontology Molecular function deaminase activity zinc ion binding metal ion binding hydrolase activity purine nucleoside binding protein binding adenosine deaminase activity Cellular component membrane cytoplasmic vesicle lumen cell surface cell junction neuronal cell body dendrite cytoplasm cytoplasmic vesicle external side of plasma membrane extracellular space cytoplasm lysosome cytosol plasma membrane Biological process positive regulation of T cell differentiation histamine secretion negative regulation of circadian sleep/wake cycle, non-REM sleep purine nucleotide salvage positive regulation of T cell differentiation in thymus positive regulation of calcium-mediated signaling xanthine biosynthetic process response to hypoxia lung development placenta development deoxyadenosine catabolic process positive regulation of T cell receptor signaling pathway adenosine metabolic process purine-containing compound salvage dATP catabolic process human ageing negative regulation of thymocyte apoptotic process negative regulation of apoptotic process in utero embryonic development negative regulation of mature B cell apoptotic process nucleotide metabolic process response to vitamin E positive regulation of heart rate negative regulation of adenosine receptor signaling pathway response to morphine regulation of cell-cell adhesion mediated by integrin T cell activation cell adhesion positive regulation of T cell activation positive regulation of B cell proliferation trophectodermal cell differentiation regulation of circadian sleep/wake cycle, sleep hypoxanthine biosynthetic process purine ribonucleoside monophosphate biosynthetic process germinal center B cell differentiation liver development lung alveolus development Peyer's patch development negative regulation of mucus secretion inosine biosynthetic process positive regulation of smooth muscle contraction negative regulation of inflammatory response negative regulation of leukocyte migration positive regulation of germinal center formation positive regulation of alpha-beta T cell differentiation embryonic digestive tract development negative regulation of penile erection regulation of T cell differentiation response to hydrogen peroxide adenosine catabolic process hypoxanthine salvage Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 100 11486 Ensembl ENSG00000196839 ENSMUSG00000017697 UniProt P00813 P03958 RefSeq (mRNA) NM_000022 NM_001322050 NM_001322051 NM_001272052 NM_007398 RefSeq (protein) NP_000013 NP_001308979 NP_001308980 NP_001258981 NP_031424 Location (UCSC) Chr 20: 44.58 – 44.65 Mb Chr 2: 163.57 – 163.59 Mb PubMed search [3] [4]
Wikidata
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Adenosine/AMP deaminase
crystal structure of plasmodium yoelii adenosine deaminase (py02076)
Identifiers
Symbol	A_deaminase
Pfam	PF00962
Pfam clan	CL0034
InterPro	IPR001365
PROSITE	PDOC00419
SCOP2	1add / SCOPe / SUPFAM
CDD	cd01320
Available protein structures: Pfam   structures / ECOD   PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

Adenosine deaminase (also known as adenosine aminohydrolase, or ADA) is an enzyme (EC 3.5.4.4) involved in purine metabolism. It is needed for the breakdown of adenosine from food and for the turnover of nucleic acids in tissues.

Its primary function in humans is the development and maintenance of the immune system.^[5] However, the full physiological role of ADA is not yet completely understood.^[6]