Adenosine receptor

Part of a series on
Purinergic signalling
Simplified illustration of extracellular purinergic signalling
Concepts

Purinergic signalling

Membrane transporters

Nucleoside transporters

The adenosine receptors (or P1 receptors[1]) are a class of purinergic G protein-coupled receptors with adenosine as the endogenous ligand.[2] There are four known types of adenosine receptors in humans: A1, A2A, A2B and A3; each is encoded by a different gene.

The adenosine receptors are commonly known for their antagonists caffeine, theophylline, and theobromine, whose action on the receptors produces the stimulating effects of coffee, tea and chocolate.

  1. ^ Fredholm BB, Abbracchio MP, Burnstock G, Dubyak GR, Harden TK, Jacobson KA, Schwabe U, Williams M (1997). "Towards a revised nomenclature for P1 and P2 receptors". Trends Pharmacol. Sci. 18 (3): 79–82. doi:10.1016/S0165-6147(96)01038-3. PMC 4460977. PMID 9133776.
  2. ^ Fredholm BB, IJzerman AP, Jacobson KA, Klotz KN, Linden J (2001). "International Union of Pharmacology. XXV. Nomenclature and classification of adenosine receptors". Pharmacol. Rev. 53 (4): 527–52. PMID 11734617.