Adherens junction

Principal interactions of structural proteins at cadherin-based adherens junction. Actin filaments are associated with adherens junctions in addition to several other actin-binding proteins such as vinculin. The head domain of vinculin associates to E-cadherin via α-, β - and γ -catenins. The tail domain of vinculin binds to membrane lipids and to actin filaments.
Adherens junction
Details
Identifiers
Latinjunctio adhaesionis
MeSHD022005
THH1.00.01.1.02002
FMA67400
Anatomical terminology

In cell biology, adherens junctions (or zonula adherens, intermediate junction, or "belt desmosome"[1]) are protein complexes that occur at cell–cell junctions and cell–matrix junctions in epithelial and endothelial tissues,[2] usually more basal than tight junctions. An adherens junction is defined as a cell junction whose cytoplasmic face is linked to the actin cytoskeleton. They can appear as bands encircling the cell (zonula adherens) or as spots of attachment to the extracellular matrix (focal adhesion).

Adherens junctions uniquely disassemble in uterine epithelial cells to allow the blastocyst to penetrate between epithelial cells.[3]

A similar cell junction in non-epithelial, non-endothelial cells is the fascia adherens. It is structurally the same, but appears in ribbonlike patterns that do not completely encircle the cells. One example is in cardiomyocytes.

  1. ^ Pardo, JV, Craig, SW (1979). "alpha-Actinin localization in the junctional complex of intestinal epithelial cells". J Cell Biol. 80 (1): 203–210. doi:10.1083/jcb.80.1.203. PMC 2110298. PMID 370125. Retrieved 15 October 2014.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  2. ^ Guo, Renyong; Sakamoto, Hiroshi; Sugiura, Shigeki (October 2006). "Endothelial Cell Motility Is Compatible With Junctional Integrity". Journal of Cellular Physiology. 211 (2): 327–335. doi:10.1002/jcp.20937. PMID 17167782. S2CID 11590025.
  3. ^ Dowland S, Madawala R, Lindsay L, Murphy C (2016). "The adherens junction is lost during normal pregnancy but not during ovarian hyperstimulated pregnancy". Acta Histochemica. 118 (2): 137–143. doi:10.1016/j.acthis.2015.12.004. PMID 26738975.