Adiponectin receptor 1

ADIPOR1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3WXV
Identifiers
Aliases	ADIPOR1, adiponectin receptor 1, ACDCR1, CGI45, PAQR1, TESBP1A, CGI-45
External IDs	OMIM: 607945; MGI: 1919924; HomoloGene: 69199; GeneCards: ADIPOR1; OMA:ADIPOR1 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	202,958,572 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	134,361,089 bp
RNA expression pattern
	Top expressed in
	blood; ; monocyte; ; skin of leg; ; bone marrow; ; skin of abdomen; ; islet of Langerhans; ; olfactory zone of nasal mucosa; ; right lung; ; minor salivary glands; ; upper lobe of left lung;
	Top expressed in
	blood; ; granulocyte; ; stroma of bone marrow; ; knee joint; ; fetal liver hematopoietic progenitor cell; ; neural layer of retina; ; triceps brachii muscle; ; atrium; ; medial head of gastrocnemius muscle; ; ankle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	adipokinetic hormone receptor activity; adiponectin binding; metal ion binding; identical protein binding; protein heterodimerization activity; protein kinase binding; signaling receptor activity;
Cellular component	integral component of membrane; membrane; intrinsic component of plasma membrane; plasma membrane;
Biological process	glucose homeostasis; lipid metabolism; leptin-mediated signaling pathway; adiponectin-activated signaling pathway; fatty acid metabolic process; regulation of lipid metabolic process; regulation of glucose metabolic process; negative regulation of cell growth; fatty acid oxidation; hormone-mediated signaling pathway; positive regulation of insulin receptor signaling pathway; positive regulation of receptor signaling pathway via JAK-STAT; negative regulation of epithelial to mesenchymal transition; negative regulation of receptor signaling pathway via JAK-STAT; negative regulation of epithelial cell migration; negative regulation of NIK/NF-kappaB signaling; G protein-coupled receptor signaling pathway; regulation of fatty acid biosynthetic process; positive regulation of cold-induced thermogenesis;
	Sources:Amigo / QuickGO
Orthologs
	51094
	72674
	ENSG00000159346
	ENSMUSG00000026457
	Q96A54
	Q91VH1
	NM_001290553; NM_001290557; NM_001290629; NM_015999
	NM_028320; NM_001306069
	NP_001277482; NP_001277486; NP_001277558; NP_057083
	NP_001292998; NP_082596
	Wikidata
View/Edit Human	View/Edit Mouse

Adiponectin receptor 1 (AdipoR1) is a protein which in humans is encoded by the ADIPOR1 gene.^[5] It is a member of the progestin and adipoQ receptor (PAQR) family, and is also known as PAQR1.^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000159346 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000026457 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Yamauchi T, Kamon J, Ito Y, Tsuchida A, Yokomizo T, Kita S, et al. (June 2003). "Cloning of adiponectin receptors that mediate antidiabetic metabolic effects". Nature. 423 (6941): 762–9. Bibcode:2003Natur.423..762Y. doi:10.1038/nature01705. PMID 12802337. S2CID 52860797.
^ Tang YT, Hu T, Arterburn M, Boyle B, Bright JM, Emtage PC, et al. (September 2005). "PAQR proteins: a novel membrane receptor family defined by an ancient 7-transmembrane pass motif". Journal of Molecular Evolution. 61 (3): 372–80. Bibcode:2005JMolE..61..372T. doi:10.1007/s00239-004-0375-2. PMID 16044242. S2CID 31473802.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000159346 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000026457 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12802337-5] Yamauchi T, Kamon J, Ito Y, Tsuchida A, Yokomizo T, Kita S, et al. (June 2003). "Cloning of adiponectin receptors that mediate antidiabetic metabolic effects". Nature. 423 (6941): 762–9. Bibcode:2003Natur.423..762Y. doi:10.1038/nature01705. PMID 12802337. S2CID 52860797.

[TangHu2005-6] Tang YT, Hu T, Arterburn M, Boyle B, Bright JM, Emtage PC, et al. (September 2005). "PAQR proteins: a novel membrane receptor family defined by an ancient 7-transmembrane pass motif". Journal of Molecular Evolution. 61 (3): 372–80. Bibcode:2005JMolE..61..372T. doi:10.1007/s00239-004-0375-2. PMID 16044242. S2CID 31473802.

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