Adiponectin receptor 2

ADIPOR2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3WXW
Identifiers
Aliases	ADIPOR2, adiponectin receptor 2, ACDCR2, PAQR2
External IDs	OMIM: 607946; MGI: 93830; HomoloGene: 56119; GeneCards: ADIPOR2; OMA:ADIPOR2 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	1,788,674 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	119,394,665 bp
RNA expression pattern
	Top expressed in
	corpus callosum; ; C1 segment; ; right adrenal cortex; ; right lung; ; left adrenal gland; ; left adrenal cortex; ; substantia nigra; ; liver; ; epithelium of colon; ; hippocampus proper;
	Top expressed in
	lactiferous gland; ; brown adipose tissue; ; transitional epithelium of urinary bladder; ; vestibular membrane of cochlear duct; ; epithelium of small intestine; ; epithelium of stomach; ; pyloric antrum; ; left lobe of liver; ; white adipose tissue; ; tunica adventitia of aorta;
	More reference expression data
	n/a
Gene ontology
Molecular function	adipokinetic hormone receptor activity; adiponectin binding; metal ion binding; identical protein binding; protein heterodimerization activity; signaling receptor activity;
Cellular component	integral component of membrane; membrane; intrinsic component of plasma membrane; plasma membrane;
Biological process	positive regulation of glucose import; glucose homeostasis; response to nutrient; lipid metabolism; female pregnancy; adiponectin-activated signaling pathway; fatty acid metabolic process; vascular wound healing; heart development; negative regulation of cell growth; fatty acid oxidation; hormone-mediated signaling pathway; regulation of fatty acid biosynthetic process; positive regulation of cold-induced thermogenesis;
	Sources:Amigo / QuickGO
Orthologs
	79602
	68465
	ENSG00000006831; ENSG00000285070
	ENSMUSG00000030168
	Q86V24
	Q8BQS5
	NM_024551; NM_001375363; NM_001375364; NM_001375365
	NM_197985; NM_001355692
	NP_078827; NP_001362292; NP_001362293; NP_001362294
	NP_932102; NP_001342621
	Wikidata
View/Edit Human	View/Edit Mouse

Adiponectin receptor 2 (AdipoR2) is a protein which in humans is encoded by the ADIPOR2 gene.^[5] It is a member of the progestin and adipoQ receptor (PAQR) family, and is also known as PAQR2.^[6]

^ ^a ^b ^c ENSG00000285070 GRCh38: Ensembl release 89: ENSG00000006831, ENSG00000285070 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000030168 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Yamauchi T, Kamon J, Ito Y, Tsuchida A, Yokomizo T, Kita S, Sugiyama T, Miyagishi M, Hara K, Tsunoda M, Murakami K, Ohteki T, Uchida S, Takekawa S, Waki H, Tsuno NH, Shibata Y, Terauchi Y, Froguel P, Tobe K, Koyasu S, Taira K, Kitamura T, Shimizu T, Nagai R, Kadowaki T (June 2003). "Cloning of adiponectin receptors that mediate antidiabetic metabolic effects". Nature. 423 (6941): 762–9. Bibcode:2003Natur.423..762Y. doi:10.1038/nature01705. PMID 12802337. S2CID 52860797.
^ Tang YT, Hu T, Arterburn M, Boyle B, Bright JM, Emtage PC, Funk WD (September 2005). "PAQR proteins: a novel membrane receptor family defined by an ancient 7-transmembrane pass motif". Journal of Molecular Evolution. 61 (3): 372–80. Bibcode:2005JMolE..61..372T. doi:10.1007/s00239-004-0375-2. PMID 16044242. S2CID 31473802.

[refGRCh38Ensembl-1] ENSG00000285070 GRCh38: Ensembl release 89: ENSG00000006831, ENSG00000285070 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000030168 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12802337-5] Yamauchi T, Kamon J, Ito Y, Tsuchida A, Yokomizo T, Kita S, Sugiyama T, Miyagishi M, Hara K, Tsunoda M, Murakami K, Ohteki T, Uchida S, Takekawa S, Waki H, Tsuno NH, Shibata Y, Terauchi Y, Froguel P, Tobe K, Koyasu S, Taira K, Kitamura T, Shimizu T, Nagai R, Kadowaki T (June 2003). "Cloning of adiponectin receptors that mediate antidiabetic metabolic effects". Nature. 423 (6941): 762–9. Bibcode:2003Natur.423..762Y. doi:10.1038/nature01705. PMID 12802337. S2CID 52860797.

[TangHu2005-6] Tang YT, Hu T, Arterburn M, Boyle B, Bright JM, Emtage PC, Funk WD (September 2005). "PAQR proteins: a novel membrane receptor family defined by an ancient 7-transmembrane pass motif". Journal of Molecular Evolution. 61 (3): 372–80. Bibcode:2005JMolE..61..372T. doi:10.1007/s00239-004-0375-2. PMID 16044242. S2CID 31473802.

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