Africatown or Little Africa may refer to:
- Africatown in Mobile, Alabama, generally referred to as "Africatown USA"
- Africatown Seattle, various organizations in the Central District of the U.S. city of Seattle
- Africville, in Halifax, Nova Scotia, Canada.
- Greenwood District, Tulsa, variously known as "Africa Town", "Negro Wall Street", and "Black Wall Street" until the Tulsa race massacre of 1921
- Kavir National Park in Iran is sometimes known as "Little Africa"
- Little Africa, South Carolina
- Little Africa, an area, the centre of which is Pedra do Sal, Saúde, Rio de Janeiro, Brazil
- Little Africa, in New York City a historic name for several neighborhoods: