Aggrecan

ACAN
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesACAN, AGC1, AGCAN, CSPG1, CSPGCP, MSK16, SEDK, Aggrecan, SSOAOD
External IDsOMIM: 155760; MGI: 99602; HomoloGene: 136177; GeneCards: ACAN; OMA:ACAN - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001135
NM_013227
NM_001369268

NM_007424
NM_001361500

RefSeq (protein)

NP_001126
NP_037359
NP_001356197

NP_031450
NP_001348429

Location (UCSC)Chr 15: 88.8 – 88.88 MbChr 7: 78.7 – 78.76 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Aggrecan (ACAN), also known as cartilage-specific proteoglycan core protein (CSPCP) or chondroitin sulfate proteoglycan 1, is a protein that in humans is encoded by the ACAN gene.[5] This gene is a member of the lectican (chondroitin sulfate proteoglycan) family. The encoded protein is an integral part of the extracellular matrix in cartilagenous tissue and it withstands compression in cartilage.

Aggrecan is a proteoglycan, or a protein modified with large carbohydrates; the human form of the protein is 2316 amino acids long and can be expressed in multiple isoforms due to alternative splicing.[5] Aggrecan was named for its ability to form large aggregates in the cartilage tissue (a large aggregating proteoglycan).[6] [7]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000157766Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030607Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b Doege KJ, Sasaki M, Kimura T, Yamada Y (January 1991). "Complete coding sequence and deduced primary structure of the human cartilage large aggregating proteoglycan, aggrecan. Human-specific repeats, and additional alternatively spliced forms". J. Biol. Chem. 266 (2): 894–902. doi:10.1016/S0021-9258(17)35257-2. PMID 1985970.
  6. ^ Aspberg A (December 2012). "The different roles of aggrecan interaction domains". The Journal of Histochemistry and Cytochemistry. 60 (12): 987–96. doi:10.1369/0022155412464376. PMC 3527881. PMID 23019016.
  7. ^ Chremos A, Horkay F (September 2023). "Coexistence of Crumpling and Flat Sheet Conformations in Two-Dimensional Polymer Networks: An Understanding of Aggrecan Self-Assembly". Physical Review Letters. 131 (13): 138101. Bibcode:2023PhRvL.131m8101C. doi:10.1103/PhysRevLett.131.138101. PMID 37832020. S2CID 263252529.