The Alfredo Guati Rojo National Watercolor Museum (Museo Nacional de Acuarela Alfredo Guati Rojo) was the first museum in the world dedicated specifically to watercolor painting. It is located in the Coyoacán borough of Mexico City, in a former private house which was donated to the museum by the city government. Due to the public health emergency, as of March 2022 the museum was still closed to casual public visits.
The museum was founded and run by artist Alfredo Guati Rojo from its beginnings in 1964 until his death in 2003. It is dedicated to the preservation and continuance of watercolor painting both in Mexico and abroad, with its permanent collection of 300 works donated by Guati Rojo and his wife, classes in watercolor and drawing, its annual Premio Nacional de Acuarela (National Watercolor Prize) and various temporary exhibits both at the museum and abroad.