Allobarbital

Allobarbital
Clinical data
Other names	5,5-Diallylbarbituric acid, Allobarbital
Drug class	Barbiturate
ATC code	N05CA21 (WHO) ;
Legal status
Legal status	BR: Class B1 (Psychoactive drugs); CA: Schedule IV; DE: Anlage III (Special prescription form required); US: Schedule III;
Identifiers
	IUPAC name 5,5-di(prop-2-en-1-yl)-1,3-diazinane-2,4,6-trione;
CAS Number	52-43-7 ;
PubChem CID	5842;
ChemSpider	5635 ;
UNII	8NT43GG2HA;
KEGG	D02817 ;
ChEMBL	ChEMBL267719 ;
CompTox Dashboard (EPA)	DTXSID9022572 ;
ECHA InfoCard	100.000.129
Chemical and physical data
Formula	C10H12N2O3
Molar mass	208.217 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C1NC(=O)NC(=O)C1(C\C=C)C\C=C;
	InChI InChI=1S/C10H12N2O3/c1-3-5-10(6-4-2)7(13)11-9(15)12-8(10)14/h3-4H,1-2,5-6H2,(H2,11,12,13,14,15) ; Key:FDQGNLOWMMVRQL-UHFFFAOYSA-N ;
	(verify)

Allobarbital, also known as allobarbitone and branded as Dial, Cibalgine (in combination with aminophenazone), or Dial-Ciba (in combination with ethyl carbamate), is a barbiturate derivative invented in 1912 by Ernst Preiswerk and Ernst Grether working for CIBA. It was used primarily as an anticonvulsant^[2] although it has now largely been replaced by newer drugs with improved safety profiles. Other uses for allobarbital included as an adjutant to boost the activity of analgesic drugs, and use in the treatment of insomnia and anxiety.

Allobarbital was never particularly widely used compared to better known barbiturates such as phenobarbital and secobarbital, although it saw more use in some European countries such as Bulgaria and Slovakia,^[3] and is still used in for example Poland, but only as compound.^[4]

^ Anvisa (2023-03-31). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 2023-04-04). Archived from the original on 2023-08-03. Retrieved 2023-08-16.
^ Chocholová L, Radil-Weiss T (1971). "Effect of allobarbital on focal epilepsy in rats". Physiologia Bohemoslovaca. 20 (4): 325–34. PMID 4335127.
^ Getova D, Georgiev V (1987). "GABA-ergic mechanisms in the anticonvulsive activity of newly-synthesized barbiturates. I. Effects of barbiturates on the convulsive action of GABA-antagonists". Acta Physiologica et Pharmacologica Bulgarica. 13 (3): 43–50. PMID 3439474.
^ "APTECZKA BABUNI - KROPLE ŻOŁĄDKOWE KROPLE 20 G" [GRANDMA'S FIRST AID KIT - DROPS - STOMACH DROPS 20 G]. Domzdrowia.pl (in Polish). Archived from the original on October 31, 2007. Retrieved March 10, 2013.

[1] Anvisa (2023-03-31). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 2023-04-04). Archived from the original on 2023-08-03. Retrieved 2023-08-16.

[2] Chocholová L, Radil-Weiss T (1971). "Effect of allobarbital on focal epilepsy in rats". Physiologia Bohemoslovaca. 20 (4): 325–34. PMID 4335127.

[3] Getova D, Georgiev V (1987). "GABA-ergic mechanisms in the anticonvulsive activity of newly-synthesized barbiturates. I. Effects of barbiturates on the convulsive action of GABA-antagonists". Acta Physiologica et Pharmacologica Bulgarica. 13 (3): 43–50. PMID 3439474.

[4] "APTECZKA BABUNI - KROPLE ŻOŁĄDKOWE KROPLE 20 G" [GRANDMA'S FIRST AID KIT - DROPS - STOMACH DROPS 20 G]. Domzdrowia.pl (in Polish). Archived from the original on October 31, 2007. Retrieved March 10, 2013.

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