Alpha-ketoglutarate-dependent hydroxylases

Alpha-ketoglutarate-dependent hydroxylases are a major class of non-heme iron proteins that catalyse a wide range of reactions. These reactions include hydroxylation reactions, demethylations, ring expansions, ring closures, and desaturations.[1][2] Functionally, the αKG-dependent hydroxylases are comparable to cytochrome P450 enzymes. Both use O2 and reducing equivalents as cosubstrates and both generate water.[3]

  1. ^ Flashman E, Schofield CJ (February 2007). "The most versatile of all reactive intermediates?". Nat. Chem. Biol. 3 (2): 86–87. doi:10.1038/nchembio0207-86. PMID 17235343.
  2. ^ Hausinger RP (January–February 2004). "Fe(II)/α-ketoglutarate-dependent hydroxylases and related enzymes". Crit. Rev. Biochem. Mol. Biol. 39 (1): 21–68. doi:10.1080/10409230490440541. PMID 15121720. S2CID 85784668.
  3. ^ Solomon EI, Decker A, Lehnert N (April 2003). "Non-heme iron enzymes: contrasts to heme catalysis". Proc. Natl. Acad. Sci. U.S.A. 100 (7): 3589–3594. doi:10.1073/pnas.0336792100. PMC 152966. PMID 12598659.