Alzheimer's Disease Neuroimaging Initiative

Alzheimer's Disease Neuroimaging Initiative (ADNI) is a multisite study that aims to improve clinical trials for the prevention and treatment of Alzheimer's disease (AD).[1] This cooperative study combines expertise and funding from the private and public sector to study subjects with AD, as well as those who may develop AD and controls with no signs of cognitive impairment.[2] Researchers at 63 sites in the US and Canada track the progression of AD in the human brain with neuroimaging, biochemical, and genetic biological markers.[2][3] This knowledge helps to find better clinical trials for the prevention and treatment of AD. ADNI has made a global impact,[4] firstly by developing a set of standardized protocols to allow the comparison of results from multiple centers,[4] and secondly by its data-sharing policy which makes available all at the data without embargo to qualified researchers worldwide.[5] To date, over 1000 scientific publications have used ADNI data.[6] A number of other initiatives related to AD and other diseases have been designed and implemented using ADNI as a model.[4] ADNI has been running since 2004 and is currently funded until 2021.[7]

  1. ^ Mueller, Susanne G.; Weiner, Michael W.; Thal, Leon J.; Petersen, Ronald C.; Jack, Clifford; Jagust, William; Trojanowski, John Q.; Toga, Arthur W.; Beckett, Laurel (2017-01-04). "The Alzheimer's Disease Neuroimaging Initiative". Neuroimaging Clinics of North America. 15 (4): 869–xii. doi:10.1016/j.nic.2005.09.008. ISSN 1052-5149. PMC 2376747. PMID 16443497.
  2. ^ a b Weiner, Michael W.; Aisen, Paul S.; Jack, Clifford R.; Jagust, William J.; Trojanowski, John Q.; Shaw, Leslie; Saykin, Andrew J.; Morris, John C.; Cairns, Nigel (2010-05-01). "The Alzheimer's disease neuroimaging initiative: progress report and future plans". Alzheimer's & Dementia: The Journal of the Alzheimer's Association. 6 (3): 202–211.e7. doi:10.1016/j.jalz.2010.03.007. ISSN 1552-5279. PMC 2927112. PMID 20451868.
  3. ^ Jones-Davis, Dorothy M.; Buckholtz, Neil (2015-07-01). "The impact of the Alzheimer's Disease Neuroimaging Initiative 2: What role do public-private partnerships have in pushing the boundaries of clinical and basic science research on Alzheimer's disease?". Alzheimer's & Dementia: The Journal of the Alzheimer's Association. 11 (7): 860–864. doi:10.1016/j.jalz.2015.05.006. ISSN 1552-5279. PMC 4513361. PMID 26194319.
  4. ^ a b c Weiner, Michael W.; Veitch, Dallas P.; Aisen, Paul S.; Beckett, Laurel A.; Cairns, Nigel J.; Cedarbaum, Jesse; Donohue, Michael C.; Green, Robert C.; Harvey, Danielle (2015-07-01). "Impact of the Alzheimer's Disease Neuroimaging Initiative, 2004 to 2014". Alzheimer's & Dementia: The Journal of the Alzheimer's Association. 11 (7): 865–884. doi:10.1016/j.jalz.2015.04.005. ISSN 1552-5279. PMC 4659407. PMID 26194320.
  5. ^ Toga, Arthur W.; Crawford, Karen L. (2015-07-01). "The Alzheimer's Disease Neuroimaging Initiative informatics core: A decade in review". Alzheimer's & Dementia: The Journal of the Alzheimer's Association. 11 (7): 832–839. doi:10.1016/j.jalz.2015.04.004. ISSN 1552-5279. PMC 4510464. PMID 26194316.
  6. ^ Weiner, Michael W.; Veitch, Dallas P.; Aisen, Paul S.; Beckett, Laurel A.; Cairns, Nigel J.; Cedarbaum, Jesse; Green, Robert C.; Harvey, Danielle; Jack, Clifford R. (2015-06-01). "2014 Update of the Alzheimer's Disease Neuroimaging Initiative: A review of papers published since its inception". Alzheimer's & Dementia: The Journal of the Alzheimer's Association. 11 (6): e1–120. doi:10.1016/j.jalz.2014.11.001. ISSN 1552-5279. PMC 5469297. PMID 26073027.
  7. ^ Weiner, Michael W.; Veitch, Dallas P.; Aisen, Paul S.; Beckett, Laurel A.; Cairns, Nigel J.; Green, Robert C.; Harvey, Danielle; Jack, Clifford R.; Jagust, William (2016-12-05). "The Alzheimer's Disease Neuroimaging Initiative 3: Continued innovation for clinical trial improvement". Alzheimer's & Dementia: The Journal of the Alzheimer's Association. 13 (5): 561–571. doi:10.1016/j.jalz.2016.10.006. ISSN 1552-5279. PMC 5536850. PMID 27931796.