Aminocoumarin

Aminocoumarin is a class of antibiotics that act by an inhibition of the DNA gyrase enzyme involved in the cell division in bacteria. They are derived from Streptomyces species,^[1] whose best-known representative – Streptomyces coelicolor – was completely sequenced in 2002.^[2] The aminocoumarin antibiotics include:^[3]

Novobiocin, Albamycin (Pharmacia And Upjohn)
Coumermycin
Clorobiocin

^ Heide, L. (2009). "Chapter 18 Aminocoumarins". Complex Enzymes in Microbial Natural Product Biosynthesis, Part B: Polyketides, Aminocoumarins and Carbohydrates. Methods in Enzymology. Vol. 459. pp. 437–455. doi:10.1016/S0076-6879(09)04618-7. ISBN 9780123745910. PMID 19362650.
^ Bentley, SD; et al. (2002). "Complete genome sequence of the model actinomycete "Streptomyces coelicolor" A3(2)". Nature. 417 (6885): 141–147. Bibcode:2002Natur.417..141B. doi:10.1038/417141a. PMID 12000953. S2CID 4430218.
^ Sonia Ilaria Maffioli (2014). "A Chemist's Survey of Different Antibiotic Classes". In Claudio O. Gualerzi; Letizia Brandi; Attilio Fabbretti; Cynthia L. Pon. (eds.). Antibiotics: Targets, Mechanisms and Resistance. Wiley-VCH. ISBN 9783527659685.

[1] Heide, L. (2009). "Chapter 18 Aminocoumarins". Complex Enzymes in Microbial Natural Product Biosynthesis, Part B: Polyketides, Aminocoumarins and Carbohydrates. Methods in Enzymology. Vol. 459. pp. 437–455. doi:10.1016/S0076-6879(09)04618-7. ISBN 9780123745910. PMID 19362650.

[2] Bentley, SD; et al. (2002). "Complete genome sequence of the model actinomycete "Streptomyces coelicolor" A3(2)". Nature. 417 (6885): 141–147. Bibcode:2002Natur.417..141B. doi:10.1038/417141a. PMID 12000953. S2CID 4430218.

[3] Sonia Ilaria Maffioli (2014). "A Chemist's Survey of Different Antibiotic Classes". In Claudio O. Gualerzi; Letizia Brandi; Attilio Fabbretti; Cynthia L. Pon. (eds.). Antibiotics: Targets, Mechanisms and Resistance. Wiley-VCH. ISBN 9783527659685.

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