Amphenicols are a class of antibiotics with a phenylpropanoid structure. They function by blocking the enzyme peptidyl transferase on the 50S ribosome subunit of bacteria.[1]
Examples of amphenicols include chloramphenicol, thiamphenicol, azidamfenicol, and florfenicol. The first-in-class compound was chloramphenicol, introduced in 1949. Chloramphenicol was initially discovered as a natural product and isolated from the soil bacteria Steptomyces venezuelae;[2] however, all amphenicols are now made by chemical synthesis.[3]
- ^ "APVMA: Florfenicol". Archived from the original on 2007-09-07. Retrieved 2007-07-22.
- ^ Scholar, Eric (2007). "Chloramphenicol". X Pharm: The Comprehensive Pharmacology Reference. pp. 1–7. doi:10.1016/B978-008055232-3.61439-4. ISBN 9780080552323.
- ^ Berendsen, Bjorn; Stolker, Linda; De Jong, Jacob; Nielen, Michel; Tserendorj, Enkhtuya; Sodnomdarjaa, Ruuragchas; Cannavan, Andrew; Elliott, Christopher (2010). "Evidence of natural occurrence of the banned antibiotic chloramphenicol in herbs and grass". Analytical and Bioanalytical Chemistry. 397 (5): 1955–1963. doi:10.1007/s00216-010-3724-6. PMC 2886120. PMID 20431869.