Amsacrine

Amsacrine
Clinical data
ATC code
Legal status
Legal status
  • US: a
Pharmacokinetic data
Protein binding96 to 98%
Elimination half-life8–9 hours
Identifiers
  • N-(4-(acridin-9-ylamino)-3-methoxyphenyl)methanesulfonamide
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.051.887 Edit this at Wikidata
Chemical and physical data
FormulaC21H19N3O3S
Molar mass393.46 g·mol−1
3D model (JSmol)
  • O=S(=O)(Nc1ccc(c(OC)c1)Nc2c4c(nc3c2cccc3)cccc4)C
  • InChI=1S/C21H19N3O3S/c1-27-20-13-14(24-28(2,25)26)11-12-19(20)23-21-15-7-3-5-9-17(15)22-18-10-6-4-8-16(18)21/h3-13,24H,1-2H3,(H,22,23) checkY
  • Key:XCPGHVQEEXUHNC-UHFFFAOYSA-N checkY
  (verify)

Amsacrine (synonyms: m-AMSA, acridinyl anisidide) is an antineoplastic agent.

It has been used in acute lymphoblastic leukemia.[1]

  1. ^ Horstmann MA, Hassenpflug WA, zur Stadt U, Escherich G, Janka G, Kabisch H (December 2005). "Amsacrine combined with etoposide and high-dose methylprednisolone as salvage therapy in acute lymphoblastic leukemia in children". Haematologica. 90 (12): 1701–3. PMID 16330449.