Amycolatopsis orientalis

Amycolatopsis orientalis
Scientific classification
Domain:	Bacteria
Phylum:	Actinomycetota
Class:	Actinomycetia
Order:	Pseudonocardiales
Family:	Pseudonocardiaceae
Genus:	Amycolatopsis
Species:	A. orientalis
Binomial name
	Amycolatopsis orientalis; (Pittenger and Brigham 1956) Lechevalier et al. 1986
Type strain
	ATCC 19795; CIP 107113; DSM 40040; IFO 12806; ISP 5040; JCM 4235; JCM 4600; NBRC 12806; NRRL 2450; UNIQEM 181; VKM Ac-866
Synonyms
	Nocardia orientalis (Pittenger and Brigham 1956) Pridham and Lyons 1969 (Approved Lists 1980); "Streptomyces orientalis" Pittenger and Brigham 1956;

Amycolatopsis orientalis is a Gram-positive bacterium in the phylum Actinomycetota.^[1]^[2] It produces several substances with antimicrobial properties, including the antibiotic drug vancomycin.^[3]^[4]

^ ^a ^b Lechevalier MP, Prauser H, Labeda DP, Ruan JS. (1986). "Two new genera of nocardioform actinomycetes: Amycolata gen. nov. and Amycolatopsis gen. nov". Int. J. Syst. Bacteriol. 36: 29–37. doi:10.1099/00207713-36-1-29.
^ Grayson, M. Lindsay (2012). Kucers' the use of antibiotics a clinical review of antibacterial, antifungal, antiparasitic and antiviral drugs (6th ed.). Boca Raton, Florida: CRC Press. p. 569. ISBN 9781444147520.
^ Kisil OV, Efimenko TA, Efremenkova OV (October 2021). "Looking Back to Amycolatopsis: History of the Antibiotic Discovery and Future Prospects". Antibiotics. 10 (10): 1254. doi:10.3390/antibiotics10101254. PMC 8532670. PMID 34680834. There are more than 100 compounds of Amycolatopsis origin with described antibacterial activity and/or proven antibiotic biosynthesis gene presence. The most productive species are A. orientalis (12 antibiotics), A. mediterranei (5 antibiotics), and A. sulphurea (3 antibiotics).
^ Samanta, Indranil; Bandyopadhyay, Samiran (2019). Antimicrobial Resistance in Agriculture: Perspective, Policy and Mitigation. Elsevier Science. p. 205. ISBN 978-0-12-816523-2. Retrieved October 9, 2022. Kornfield, an organic chemist at Eli Lilly, first isolated a bacterium namely Amycolatopsis orientalis (Streptomyces orientalis or Nocardia orientalis) from mud collected by a missionary from forests of Borneo island. A compound ('Mississippi mud' or compound 05,865) was extracted from the isolated bacteria and it was approved by FDA as vancomycin drug after clinical trials.

[Lechevalier-1] Lechevalier MP, Prauser H, Labeda DP, Ruan JS. (1986). "Two new genera of nocardioform actinomycetes: Amycolata gen. nov. and Amycolatopsis gen. nov". Int. J. Syst. Bacteriol. 36: 29–37. doi:10.1099/00207713-36-1-29.

[2] Grayson, M. Lindsay (2012). Kucers' the use of antibiotics a clinical review of antibacterial, antifungal, antiparasitic and antiviral drugs (6th ed.). Boca Raton, Florida: CRC Press. p. 569. ISBN 9781444147520.

[pmid34680834-3] Kisil OV, Efimenko TA, Efremenkova OV (October 2021). "Looking Back to Amycolatopsis: History of the Antibiotic Discovery and Future Prospects". Antibiotics. 10 (10): 1254. doi:10.3390/antibiotics10101254. PMC 8532670. PMID 34680834. There are more than 100 compounds of Amycolatopsis origin with described antibacterial activity and/or proven antibiotic biosynthesis gene presence. The most productive species are A. orientalis (12 antibiotics), A. mediterranei (5 antibiotics), and A. sulphurea (3 antibiotics).

[Samanta2019-4] Samanta, Indranil; Bandyopadhyay, Samiran (2019). Antimicrobial Resistance in Agriculture: Perspective, Policy and Mitigation. Elsevier Science. p. 205. ISBN 978-0-12-816523-2. Retrieved October 9, 2022. Kornfield, an organic chemist at Eli Lilly, first isolated a bacterium namely Amycolatopsis orientalis (Streptomyces orientalis or Nocardia orientalis) from mud collected by a missionary from forests of Borneo island. A compound ('Mississippi mud' or compound 05,865) was extracted from the isolated bacteria and it was approved by FDA as vancomycin drug after clinical trials.

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