Anaphase lag

Anaphase lag is a consequence of an event during cell division where sister chromatids do not properly separate from each other because of improper spindle formation.[1] The chromosome or chromatid does not properly migrate during anaphase and the daughter cells will lose some genetic information. It is one of many causes of aneuploidy. This event can occur during both meiosis and mitosis with unique repercussions. In either case, anaphase lag will cause one daughter cell to receive a complete set of chromosomes while the other lacks one paired set of chromosomes, creating a form of monosomy.[2] Whether the cell survives depends on which sister chromatid was lost and the background genomic state of the cell. The passage of abnormal numbers of chromosomes will have unique consequences with regards to mosaicism and development as well as the progression and heterogeneity of cancers.[3]

  1. ^ "Human Molecular Genetics". Archived from the original on June 29, 2007. {{cite journal}}: Cite journal requires |journal= (help)
  2. ^ Holland, Andrew J; Cleveland, Don W (June 2012). "Losing balance: the origin and impact of aneuploidy in cancer". EMBO Reports. 13 (6): 501–514. doi:10.1038/embor.2012.55. ISSN 1469-221X. PMC 3367240. PMID 22565320.
  3. ^ Gordon, David J.; Resio, Benjamin; Pellman, David (March 2012). "Causes and consequences of aneuploidy in cancer". Nature Reviews Genetics. 13 (3): 189–203. doi:10.1038/nrg3123. ISSN 1471-0064. PMID 22269907. S2CID 4956346.