Clinical data | |
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Trade names | Arimidex, Aremed, others[1] |
Other names | Anastrazole; anastrozol; ICI-D1033; ZD-1033 |
AHFS/Drugs.com | Monograph |
MedlinePlus | a696018 |
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Routes of administration | By mouth |
Drug class | Aromatase inhibitor; Antiestrogen |
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Pharmacokinetic data | |
Bioavailability | Unknown (but well-absorbed in animals)[2] |
Protein binding | 40%[3][4] |
Metabolism | Liver (~85%) (N-dealkylation, hydroxylation, glucuronidation)[3][2][4] |
Elimination half-life | 40–50 hours[3][2][4] |
Excretion | Urine (11%)[3][2][4] |
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ECHA InfoCard | 100.129.723 |
Chemical and physical data | |
Formula | C17H19N5 |
Molar mass | 293.374 g·mol−1 |
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Anastrozole, sold under the brand name Arimidex among others, is an antiestrogenic medication used in addition to other treatments for breast cancer.[6][7] Specifically it is used for hormone receptor-positive breast cancer.[7] It has also been used to prevent breast cancer in those at high risk.[7] It is taken by mouth.[7]
Common side effects of anastrozole include hot flashes, altered mood, joint pain, and nausea.[7][6] Severe side effects include an increased risk of heart disease and osteoporosis.[7] Use during pregnancy may harm the baby.[7] Anastrozole is in the aromatase-inhibiting family of medications.[7] It works by blocking the production of estrogens in the body, and hence has antiestrogenic effects.[7]
Anastrozole was patented in 1987 and was approved for medical use in 1995.[8][9] It is on the World Health Organization's List of Essential Medicines.[10] Anastrozole is available as a generic medication.[7] In 2022, it was the 179th most commonly prescribed medication in the United States, with more than 2 million prescriptions.[11][12]
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