Androctonus australis hector insect toxin

Androctonus australis hector insect toxin
3D model of AaHIT1 residue 19-88
Names
Other NamesAaHIT or AaIT
SubtypesAaHIT1, AaHIT2, AaHIT4 and AaHIT5
Source
Latin nameAndroctonus australis hector
English nameSahara scorpion
Target
Target channelVoltage-gated sodium channels
Beta-insect excitatory toxin 1
Identifiers
OrganismAndroctonus australis
SymbolAaHIT1
UniProtP01497
Search for
StructuresSwiss-model
DomainsInterPro
Scorpion toxin-like domain
Identifiers
SymbolToxin_3
PfamPF00537
InterProIPR002061
Available protein structures:
Pfam  structures / ECOD  
PDBRCSB PDB; PDBe; PDBj
PDBsumstructure summary

Androctonus australis hector insect toxin also known as AaHIT is a scorpion toxin which affects voltage-gated sodium channels. Four different insect toxins, namely AaHIT1, AaHIT2, AaHIT4 and AaHIT5, can be distinguished. It targets insects, except AaHIT4, which is also toxic to crustaceans and mammals.[1]

  1. ^ Loret EP, Martin-Eauclaire MF, Mansuelle P, Sampieri F, Granier C, Rochat H (January 1991). "An anti-insect toxin purified from the scorpion Androctonus australis Hector also acts on the alpha- and beta-sites of the mammalian sodium channel: sequence and circular dichroism study". Biochemistry. 30 (3): 633–40. doi:10.1021/bi00217a007. PMID 1846301.