Angiogenin

ANG
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1A4Y, 1ANG, 1AWZ, 1B1E, 1B1I, 1B1J, 1GV7, 1H0D, 1H52, 1H53, 1HBY, 1K58, 1K59, 1K5A, 1K5B, 1UN3, 1UN4, 1UN5, 2ANG, 4AHD, 4AHE, 4AHF, 4AHG, 4AHH, 4AHI, 4AHJ, 4AHK, 4AHL, 4AHM, 4AHN, 4AOH, 4B36
Identifiers
Aliases	ANG, ALS9, HEL168, RAA1, RNASE4, RNASE5, angiogenin, ribonuclease, RNase A family, 5, angiogenin
External IDs	OMIM: 105850; MGI: 88022; HomoloGene: 74385; GeneCards: ANG; OMA:ANG - orthologs
Gene location (Human) Chr. Chromosome 14 (human)[1] Band 14q11.2 Start 20,684,177 bp[1] End 20,698,971 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14 C1|14 26.37 cM Start 51,328,607 bp[2] End 51,339,466 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of liver left ovary right ovary rectum body of stomach canal of the cervix gastric mucosa Descending thoracic aorta olfactory zone of nasal mucosa right lung Top expressed in left lobe of liver epithelium of stomach islet of Langerhans Paneth cell gallbladder migratory enteric neural crest cell lumbar spinal ganglion ileum ankle right lung lobe More reference expression data BioGPS n/a
Gene ontology Molecular function DNA binding rRNA binding heparin binding protein homodimerization activity peptide binding protein binding nucleic acid binding nuclease activity endonuclease activity actin binding copper ion binding signaling receptor binding hydrolase activity ribonuclease activity Cellular component extracellular region nucleolus angiogenin-PRI complex cytoplasmic vesicle nucleus extracellular space growth cone soma basement membrane Biological process cell differentiation negative regulation of smooth muscle cell proliferation negative regulation of translation activation of protein kinase B activity response to hypoxia positive regulation of endothelial cell proliferation placenta development rRNA transcription activation of phospholipase C activity activation of phospholipase A2 activity diacylglycerol biosynthetic process multicellular organism development cell communication actin filament polymerization oocyte maturation angiogenesis positive regulation of protein secretion ovarian follicle development response to hormone positive regulation of phosphorylation adherens junction organization cell migration homeostatic process nucleic acid phosphodiester bond hydrolysis RNA phosphodiester bond hydrolysis innate immune response antimicrobial humoral immune response mediated by antimicrobial peptide Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 283 11727 Ensembl ENSG00000214274 ENSMUSG00000072115 UniProt P03950 P21570 RefSeq (mRNA) NM_001145 NM_001097577 NM_001161731 NM_007447 RefSeq (protein) NP_001091046 NP_001136 NP_001155203 NP_031473 Location (UCSC) Chr 14: 20.68 – 20.7 Mb Chr 14: 51.33 – 51.34 Mb PubMed search [3] [4]
Wikidata
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Angiogenin (ANG) also known as ribonuclease 5 is a small 123 amino acid protein that in humans is encoded by the ANG gene.^[5] Angiogenin is a potent stimulator of new blood vessels through the process of angiogenesis. Ang hydrolyzes cellular RNA, resulting in modulated levels of protein synthesis and interacts with DNA causing a promoter-like increase in the expression of rRNA.^[6][7] Ang is associated with cancer and neurological disease through angiogenesis and through activating gene expression that suppresses apoptosis.^[6][8][9]