Angiolathyrism | |
---|---|
Specialty | Neurology |
Symptoms | Weakness, fatigue, paralysis of the legs, atrophy of leg muscles |
Usual onset | Gradual |
Duration | Permanent |
Types | Neurolathyrism |
Diagnostic method | Based on symptoms and diet |
Frequency | Rare |
Angiolathyrism is a form of lathyrism disease. It is mainly caused the consumption of Lathyrus sativus (also known as grass pea) and to a lesser degree by Lathyrus cicera, Lathyrus ochrus and Lathyrus clymenum[1] containing the toxin ODAP.[2] The main chemical responsible is β-Aminopropionitrile, which prevents collagen cross-linking, thus making the blood vessel, especially the tunica media, weak. This can result in Cystic medial necrosis or a picture similar to Marfan syndrome. The damaged vessels are at an increased risk of dissection.[citation needed]
Unlike osteolathyrism, the blood vessels are affected instead of bone. However it is caused by similar action and is typically associated with the other forms of lathyrism.[citation needed]