Angiopellosis

In cellular biology, angiopellosis (cell extravasation) is the movement of cells out of the circulatory system, into the surrounding tissue. This process is specific to non-leukocytic cells; white blood cells (leukocytes) employ diapedesis for movement out of circulation. Angiopellosis was discovered by studying the way that stem cells reach damaged tissue when injected or infused into the circulatory system.[1] It has been found that circulating tumor cells (CTCs) possess this ability to exit blood vessels through angiopellosis during the process of metastasis.[2]

Angiopellosis involves cell–cell recognition by the blood vessel wall (endothelial cells), and the active remodeling of the blood vessel to allow the cell to exit.[3]

  1. ^ Allen, Tyler A.; Gracieux, David; Talib, Maliha; Tokarz, Debra A.; Hensley, M. Taylor; Cores, Jhon; Vandergriff, Adam; Tang, Junnan; de Andrade, James B.M. (January 2017). "Angiopellosis as an Alternative Mechanism of Cell Extravasation". Stem Cells. 35 (1): 170–180. doi:10.1002/stem.2451. ISSN 1066-5099. PMC 5376103. PMID 27350343.
  2. ^ Allen, Tyler A.; Asad, Dana; Amu, Emmanuel; Hensley, M. Taylor; Cores, Jhon; Vandergriff, Adam; Tang, Junnan; Dinh, Phuong-Uyen; Shen, Deliang; Qiao, Li; Su, Teng (2019-09-01). "Circulating tumor cells exit circulation while maintaining multicellularity, augmenting metastatic potential". Journal of Cell Science. 132 (17): jcs231563. doi:10.1242/jcs.231563. ISSN 0021-9533. PMC 6771143. PMID 31409692.
  3. ^ "Researchers Show How Stem Cells Exit Bloodstream | Medicilon Inc". www.medicilon.com. Retrieved 2019-08-01.