| Angiopoietin receptor | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | TIE | ||||||||
| Pfam | PF10430 | ||||||||
| InterPro | IPR018941 | ||||||||
| Membranome | 1214 | ||||||||
| |||||||||
| tyrosine kinase with immunoglobulin-like and EGF-like domains 1 | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | TIE1 | ||||||
| Alt. symbols | TIE, JTK14 | ||||||
| NCBI gene | 7075 | ||||||
| HGNC | 11809 | ||||||
| OMIM | 600222 | ||||||
| RefSeq | NM_005424 | ||||||
| UniProt | P35590 | ||||||
| Other data | |||||||
| EC number | 2.7.1.112 | ||||||
| Locus | Chr. 1 p34-p33 | ||||||
| |||||||
| TEK tyrosine kinase, endothelial | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | TEK | ||||||
| Alt. symbols | TIE2, TIE-2, VMCM1, CD202b | ||||||
| NCBI gene | 7010 | ||||||
| HGNC | 11724 | ||||||
| OMIM | 600221 | ||||||
| RefSeq | NM_000459 | ||||||
| UniProt | Q02763 | ||||||
| Other data | |||||||
| Locus | Chr. 9 p21 | ||||||
| |||||||
The angiopoietin receptors are receptors that bind angiopoietin. TIE-1 and TIE-2 comprise the cell-surface receptors that bind and are activated by the angiopoietins, (Ang1, Ang2, Ang3, Ang4). The angiopoietins are protein growth factors required for the formation of blood vessels (angiogenesis).