Ankyrin-1

ANK1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1N11, 2YQF, 2YVI, 3F59, 3KBT, 3KBU, 3UD1, 3UD2
Identifiers
Aliases	ANK1, ANK, SPH1, SPH2, ankyrin 1
External IDs	OMIM: 612641; MGI: 88024; HomoloGene: 55427; GeneCards: ANK1; OMA:ANK1 - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	41,896,762 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	23,640,513 bp
RNA expression pattern
	Top expressed in
	Skeletal muscle tissue of rectus abdominis; ; triceps brachii muscle; ; body of tongue; ; biceps brachii; ; Skeletal muscle tissue of biceps brachii; ; muscle of thigh; ; thoracic diaphragm; ; apex of heart; ; glutes; ; gastrocnemius muscle;
	Top expressed in
	fetal liver hematopoietic progenitor cell; ; muscle of thigh; ; inferior colliculi; ; lobe of cerebellum; ; triceps brachii muscle; ; vastus lateralis muscle; ; pontine nuclei; ; cerebellar vermis; ; sternocleidomastoid muscle; ; skeletal muscle tissue;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	spectrin binding; ATPase binding; structural molecule activity; structural constituent of cytoskeleton; protein binding; enzyme binding; cytoskeletal anchor activity;
Cellular component	M band; cytosol; postsynaptic membrane; membrane; plasma membrane; sarcoplasmic reticulum; basolateral plasma membrane; Z discdkac; axolemma; spectrin-associated cytoskeleton; neuron projection; sarcolemma; A band; cytoskeleton; nucleus; cytoplasm;
Biological process	positive regulation of organelle organization; endoplasmic reticulum to Golgi vesicle-mediated transport; maintenance of epithelial cell apical/basal polarity; cytoskeleton organization; signal transduction; exocytosis; protein localization to plasma membrane;
	Sources:Amigo / QuickGO
Orthologs
	286
	11733
	ENSG00000029534
	ENSMUSG00000031543
	P16157
	Q02357
NM_000037; NM_001142445; NM_001142446; NM_020475; NM_020476;
	NM_020477; NM_020478; NM_020479; NM_020480; NM_020481
NM_001110783; NM_001277280; NM_001277281; NM_001277284; NM_001277286;
	NM_001277289; NM_031158; NM_001310436; NM_001310437
NP_000028; NP_001135917; NP_001135918; NP_065208; NP_065209;
	NP_065210; NP_065211; NP_065213
NP_001104253; NP_001264209; NP_001264210; NP_001264213; NP_001264215;
	NP_001264218; NP_001297365; NP_001297366; NP_112435
	Wikidata
View/Edit Human	View/Edit Mouse

Ankyrin 1, also known as ANK-1, and erythrocyte ankyrin, is a protein that in humans is encoded by the ANK1 gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000029534 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000031543 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Lambert S, Yu H, Prchal JT, Lawler J, Ruff P, Speicher D, et al. (March 1990). "cDNA sequence for human erythrocyte ankyrin". Proceedings of the National Academy of Sciences of the United States of America. 87 (5): 1730–1734. Bibcode:1990PNAS...87.1730L. doi:10.1073/pnas.87.5.1730. PMC 53556. PMID 1689849.
^ "Entrez Gene: ANK1 ankyrin 1, erythrocytic".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000029534 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000031543 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1689849-5] Lambert S, Yu H, Prchal JT, Lawler J, Ruff P, Speicher D, et al. (March 1990). "cDNA sequence for human erythrocyte ankyrin". Proceedings of the National Academy of Sciences of the United States of America. 87 (5): 1730–1734. Bibcode:1990PNAS...87.1730L. doi:10.1073/pnas.87.5.1730. PMC 53556. PMID 1689849.

[entrez_286-6] "Entrez Gene: ANK1 ankyrin 1, erythrocytic".

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