Ankyrin-3

ANK3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4O6X
Identifiers
Aliases	ANK3, ANKYRIN-G, MRT37, ankyrin 3, node of Ranvier (ankyrin G), ankyrin 3
External IDs	OMIM: 600465; MGI: 88026; HomoloGene: 56908; GeneCards: ANK3; OMA:ANK3 - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	60,733,490 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	70,027,438 bp
RNA expression pattern
	Top expressed in
	endothelial cell; ; Brodmann area 23; ; dorsal motor nucleus of vagus nerve; ; middle temporal gyrus; ; Region I of hippocampus proper; ; lateral nuclear group of thalamus; ; inferior olivary nucleus; ; postcentral gyrus; ; cerebellar vermis; ; pars compacta;
	Top expressed in
	lateral geniculate nucleus; ; pontine nuclei; ; ventromedial nucleus; ; mammillary body; ; medial geniculate nucleus; ; lateral hypothalamus; ; olfactory tubercle; ; nucleus accumbens; ; deep cerebellar nuclei; ; anterior amygdaloid area;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein-macromolecule adaptor activity; cadherin binding; cytoskeletal protein binding; structural constituent of cytoskeleton; protein binding; spectrin binding; transmembrane transporter binding;
Cellular component	cytoplasm; cytosol; Golgi apparatus; cell projection; lateral plasma membrane; membrane; bicellular tight junction; T-tubule; synapse; cell surface; axon; cell junction; basal plasma membrane; basolateral plasma membrane; endoplasmic reticulum; spectrin-associated cytoskeleton; sarcolemma; lysosome; costamere; cytoskeleton; dendrite; postsynaptic membrane; sarcoplasmic reticulum; neuron projection; neuromuscular junction; Z discdkac; plasma membrane; intercalated disc; node of Ranvier; axon initial segment;
Biological process	regulation of potassium ion transport; positive regulation of membrane depolarization during cardiac muscle cell action potential; establishment of protein localization; mitotic cytokinesis; endoplasmic reticulum to Golgi vesicle-mediated transport; maintenance of protein location in plasma membrane; positive regulation of gene expression; positive regulation of sodium ion transport; positive regulation of sodium ion transmembrane transporter activity; positive regulation of membrane potential; plasma membrane organization; signal transduction; Golgi to plasma membrane protein transport; neuromuscular junction development; positive regulation of cell communication by electrical coupling; positive regulation of homotypic cell-cell adhesion; positive regulation of protein targeting to membrane; membrane assembly; positive regulation of cation channel activity; axonogenesis; magnesium ion homeostasis; neuronal action potential; cellular response to magnesium ion; protein localization to plasma membrane; negative regulation of delayed rectifier potassium channel activity; protein localization to axon;
	Sources:Amigo / QuickGO
Orthologs
	288
	11735
	ENSG00000151150
	ENSMUSG00000069601
	Q12955
	G5E8K5
	NM_001149; NM_001204403; NM_001204404; NM_020987; NM_001320874
NM_009670; NM_146005; NM_170687; NM_170688; NM_170689;
	NM_170690; NM_170728; NM_170729; NM_170730
	NP_001140; NP_001191332; NP_001191333; NP_001307803; NP_066267
NP_033800; NP_666117; NP_733788; NP_733789; NP_733790;
	NP_733791; NP_733924; NP_733925; NP_733926
	Wikidata
View/Edit Human	View/Edit Mouse

Ankyrin-3 (ANK-3), also known as ankyrin-G, is a protein from ankyrin family that in humans is encoded by the ANK3 gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000151150 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000069601 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: ANK2 ankyrin 3, node of Ranvier".
^ Kapfhamer D, Miller DE, Lambert S, Bennett V, Glover TW, Burmeister M (May 1995). "Chromosomal localization of the ankyrinG gene (ANK3/Ank3) to human 10q21 and mouse 10". Genomics. 27 (1): 189–191. doi:10.1006/geno.1995.1023. PMID 7665168.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000151150 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000069601 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez_288-5] "Entrez Gene: ANK2 ankyrin 3, node of Ranvier".

[pmid7665168-6] Kapfhamer D, Miller DE, Lambert S, Bennett V, Glover TW, Burmeister M (May 1995). "Chromosomal localization of the ankyrinG gene (ANK3/Ank3) to human 10q21 and mouse 10". Genomics. 27 (1): 189–191. doi:10.1006/geno.1995.1023. PMID 7665168.

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