Antimutagen

Antimutagens are the agents that interfere with the mutagenicity of a substance.[1] The interference can be in the form of prevention of the transformation of a promutagenic compound into actual active mutagen, inactivation, or otherwise the prevention of Mutagen-DNA reaction.[2]

Antimutagens can be classified into: Desmutagens, that inactivate the chemical interactions before the mutagen attacks the genes and Bio-antimutagens, that stop the mutation process once after the genes are damaged by mutagens.[2] There are a number of naturally occurring anti-mutagens that show their efficient action.[3][4][5]

  1. ^ "The database and ontology of Chemical Entities of Biological Interest". EMBL-EBI, European Molecular Biology Laboratory, Wellcome Trust Genome Campus.
  2. ^ a b Kada, Tsuneo; Inoue, Tadashi; Ohta, Toshihiro; Shirasu, Yasuhiko (1986). "Antimutagens and their Modes of Action". Antimutagenesis and Anticarcinogenesis Mechanisms. Vol. 39. pp. 181–196. doi:10.1007/978-1-4684-5182-5_15. ISBN 978-1-4684-5184-9. PMID 3533041. {{cite book}}: |journal= ignored (help)
  3. ^ Renner, H.W.; Münzner, R. (April 1991). "The possible role of probiotics as dietary antimutagens". Mutation Research Letters. 262 (4): 239–245. doi:10.1016/0165-7992(91)90090-q. PMID 1708108.
  4. ^ Mitscher, Lester A.; Telikepalli, Hanumaiah; McGhee, Eva; Shankel, Delbert M. (1996-02-19). "Natural antimutagenic agents". Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 350 (1): 143–152. doi:10.1016/0027-5107(95)00099-2. PMID 8657175.
  5. ^ E. Wall, Monroe (1992). "Antimutagenic Agents from Natural Products". Journal of Natural Products. 55 (11): 1561–1568. doi:10.1021/np50089a002. PMID 1479376.