Anyuak Zone or Anywaa Zone is a zone in Gambela Region of Ethiopia. It was created from former Administrative Zone 1 and Administrative Zone 2 of Gambela. This zone is bordered on the southwest by South Sudan, on the southeast by the Southern Nations, Nationalities, and Peoples Region, on the east by Majang Zone, on the northeast by the Oromia Region, and on the northwest by South Sudan and Nuer Zone. Towns in this zone include Gambela, Abwobo and Pinyudo.
The terrain is mostly flat; rivers include the Baro, which is the only navigable river in Ethiopia, the Alworo and the Gilo; major bodies of water include Lakes Alworo and Thatha. A notable landmark is the Gambela National Park, which covers a large part of the Zone south of the Baro.