Apolipoprotein C-III

APOC3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2JQ3
Identifiers
Aliases	APOC3, APOCIII, HALP2, apolipoprotein C3, Apo-C3, ApoC-3
External IDs	OMIM: 107720; MGI: 88055; HomoloGene: 81615; GeneCards: APOC3; OMA:APOC3 - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q23.3 Start 116,829,706 bp[1] End 116,833,072 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9 A5.2|9 25.36 cM Start 46,144,231 bp[2] End 46,146,934 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in jejunal mucosa right lobe of liver mucosa of ileum duodenum gonad amniotic fluid human kidney epithelium of colon metanephros left uterine tube Top expressed in left lobe of liver duodenum jejunum migratory enteric neural crest cell yolk sac ileum right kidney proximal tubule median eminence intestinal epithelium More reference expression data BioGPS More reference expression data
Gene ontology Molecular function lipid binding lipase inhibitor activity enzyme regulator activity high-density lipoprotein particle receptor binding cholesterol binding phospholipid binding Cellular component chylomicron very-low-density lipoprotein particle spherical high-density lipoprotein particle extracellular region early endosome extracellular exosome intermediate-density lipoprotein particle extracellular space extracellular matrix collagen-containing extracellular matrix Biological process negative regulation of cholesterol import G protein-coupled receptor signaling pathway negative regulation of very-low-density lipoprotein particle remodeling lipid transport chylomicron remnant clearance negative regulation of fatty acid biosynthetic process regulation of Cdc42 protein signal transduction lipid metabolism negative regulation of high-density lipoprotein particle clearance phospholipid efflux negative regulation of low-density lipoprotein particle clearance negative regulation of very-low-density lipoprotein particle clearance retinoid metabolic process negative regulation of receptor-mediated endocytosis lipid catabolic process cholesterol efflux negative regulation of lipoprotein lipase activity cholesterol homeostasis very-low-density lipoprotein particle assembly negative regulation of triglyceride catabolic process negative regulation of lipid catabolic process negative regulation of lipid metabolic process reverse cholesterol transport triglyceride homeostasis triglyceride metabolic process triglyceride catabolic process chylomicron remodeling high-density lipoprotein particle remodeling chylomicron assembly lipoprotein metabolic process transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 345 11814 Ensembl ENSG00000110245 ENSMUSG00000032081 UniProt P02656 P33622 RefSeq (mRNA) NM_000040 NM_023114 NM_001289755 NM_001289756 NM_001289833 RefSeq (protein) NP_000031 NP_001276684 NP_001276685 NP_001276762 NP_075603 Location (UCSC) Chr 11: 116.83 – 116.83 Mb Chr 9: 46.14 – 46.15 Mb PubMed search [3] [4]
Wikidata
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Apolipoprotein C-III also known as apo-CIII, and apolipoprotein C3, is a protein that in humans is encoded by the APOC3 gene. Apo-CIII is secreted by the liver as well as the small intestine, and is found on triglyceride-rich lipoproteins such as chylomicrons, very low density lipoprotein (VLDL), and remnant cholesterol.^[5]