| apoptosis-inducing factor, mitochondrion-associated, 1 | |||||||
|---|---|---|---|---|---|---|---|
 Crystallographic structure of the human apoptosis inducing factor (rainbow color cartoon diagram, N-terminus = blue, C-terminus = red).[1] | |||||||
| Identifiers | |||||||
| Symbol | AIFM1 | ||||||
| Alt. symbols | PDCD8 | ||||||
| NCBI gene | 9131 | ||||||
| HGNC | 8768 | ||||||
| OMIM | 300169 | ||||||
| RefSeq | NM_004208 | ||||||
| UniProt | O95831 | ||||||
| Other data | |||||||
| Locus | Chr. X q25-q26 | ||||||
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Apoptosis inducing factor is involved in initiating a caspase-independent pathway of apoptosis (positive intrinsic regulator of apoptosis) by causing DNA fragmentation and chromatin condensation. Apoptosis inducing factor is a flavoprotein.[2] It also acts as an NADH oxidase. Another AIF function is to regulate the permeability of the mitochondrial membrane upon apoptosis. Normally it is found behind the outer membrane of the mitochondrion and is therefore secluded from the nucleus. However, when the mitochondrion is damaged, it moves to the cytosol and to the nucleus. Inactivation of AIF leads to resistance of embryonic stem cells to death following the withdrawal of growth factors indicating that it is involved in apoptosis.[2][3]
- ^ PDB: 1M6I; Ye H, Cande C, Stephanou NC, Jiang S, Gurbuxani S, Larochette N, Daugas E, Garrido C, Kroemer G, Wu H (September 2002). "DNA binding is required for the apoptogenic action of apoptosis inducing factor". Nature Structural Biology. 9 (9): 680–4. doi:10.1038/nsb836. PMID 12198487. S2CID 7819466.
- ^ a b Joza N, Pospisilik JA, Hangen E, Hanada T, Modjtahedi N, Penninger JM, Kroemer G (August 2009). "AIF: not just an apoptosis-inducing factor". Annals of the New York Academy of Sciences. 1171 (1): 2–11. Bibcode:2009NYASA1171....2J. doi:10.1111/j.1749-6632.2009.04681.x. PMID 19723031. S2CID 35011873.
- ^ Candé C, Cohen I, Daugas E, Ravagnan L, Larochette N, Zamzami N, Kroemer G (2002). "Apoptosis-inducing factor (AIF): a novel caspase-independent death effector released from mitochondria". Biochimie. 84 (2–3): 215–22. doi:10.1016/S0300-9084(02)01374-3. PMID 12022952.