Apoptosis regulator BAX

BAX
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4BDU, 1F16, 2G5B, 2K7W, 2LR1, 3PK1, 3PL7, 4BD2, 4BD6, 4BD7, 4BD8, 4UF2, 4ZIE, 4ZIF, 4ZIG, 4ZIH, 4ZII, 4S0O
Identifiers
Aliases	BAX, BCL2L4, BCL2 associated X protein, BCL2 associated X, apoptosis regulator
External IDs	OMIM: 600040; MGI: 99702; HomoloGene: 7242; GeneCards: BAX; OMA:BAX - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.33 Start 48,954,815 bp[1] End 48,961,798 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7 B3|7 29.32 cM Start 45,111,121 bp[2] End 45,116,322 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of transverse colon stromal cell of endometrium granulocyte monocyte gallbladder right lung rectum upper lobe of left lung spleen ascending aorta Top expressed in embryo epiblast embryo yolk sac ventricular zone neural tube stroma of bone marrow calvaria ganglionic eminence right kidney More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein homodimerization activity channel activity protein binding BH3 domain binding chaperone binding protein heterodimerization activity identical protein binding lipid binding Hsp70 protein binding Cellular component cytosol nuclear envelope membrane Bcl-2 family protein complex mitochondrion nucleus mitochondrial permeability transition pore complex mitochondrial membranes BAX complex endoplasmic reticulum extracellular exosome pore complex integral component of membrane intracellular anatomical structure endoplasmic reticulum membrane cytoplasm mitochondrial outer membrane cell periphery Biological process negative regulation of neuron apoptotic process response to ionizing radiation germ cell development positive regulation of calcium ion transport into cytosol glycosphingolipid metabolic process B cell apoptotic process response to salt stress Sertoli cell proliferation thymocyte apoptotic process T cell homeostatic proliferation post-embryonic development regulation of mitochondrial membrane permeability involved in apoptotic process negative regulation of protein binding cellular response to DNA damage stimulus regulation of mitochondrial membrane permeability involved in programmed necrotic cell death odontogenesis of dentin-containing tooth positive regulation of extrinsic apoptotic signaling pathway in absence of ligand positive regulation of IRE1-mediated unfolded protein response blood vessel remodeling positive regulation of neuron apoptotic process apoptotic process involved in blood vessel morphogenesis activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c spermatogenesis apoptotic signaling pathway cell population proliferation mitochondrion morphogenesis activation of cysteine-type endopeptidase activity involved in apoptotic process negative regulation of cell population proliferation cellular response to organic substance B cell homeostatic proliferation limb morphogenesis release of matrix enzymes from mitochondria extrinsic apoptotic signaling pathway kidney development activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway negative regulation of apoptotic signaling pathway myeloid cell homeostasis regulation of neuron apoptotic process regulation of cysteine-type endopeptidase activity involved in apoptotic process endoplasmic reticulum calcium ion homeostasis response to wounding intrinsic apoptotic signaling pathway by p53 class mediator hypothalamus development viral process protein homooligomerization response to gamma radiation negative regulation of fibroblast proliferation positive regulation of intrinsic apoptotic signaling pathway response to toxic substance B cell negative selection mitochondrial fusion neuron apoptotic process male gonad development positive regulation of B cell apoptotic process regulation of protein heterodimerization activity positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway cellular response to UV sex differentiation neuron migration B cell homeostasis positive regulation of release of sequestered calcium ion into cytosol positive regulation of apoptotic process involved in mammary gland involution nervous system development spermatid differentiation development of secondary sexual characteristics positive regulation of developmental pigmentation retina development in camera-type eye response to axon injury positive regulation of mitochondrial membrane permeability involved in apoptotic process cerebral cortex development ovarian follicle development fertilization ectopic germ cell programmed cell death homeostasis of number of cells within a tissue positive regulation of release of cytochrome c from mitochondria B cell receptor apoptotic signaling pathway negative regulation of endoplasmic reticulum calcium ion concentration regulation of protein homodimerization activity apoptotic process involved in embryonic digit morphogenesis leukocyte homeostasis positive regulation of apoptotic DNA fragmentation mitochondrial fragmentation involved in apoptotic process positive regulation of endoplasmic reticulum unfolded protein response establishment or maintenance of transmembrane electrochemical gradient homeostasis of number of cells vagina development post-embryonic camera-type eye morphogenesis regulation of mammary gland epithelial cell proliferation retinal cell programmed cell death regulation of cell cycle regulation of mitochondrial membrane potential intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress apoptotic mitochondrial changes protein complex oligomerization regulation of nitrogen utilization negative regulation of peptidyl-serine phosphorylation positive regulation of apoptotic process positive regulation of protein oligomerization extrinsic apoptotic signaling pathway via death domain receptors release of cytochrome c from mitochondria apoptotic process protein insertion into mitochondrial membrane involved in apoptotic signaling pathway intrinsic apoptotic signaling pathway regulation of apoptotic process DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest intrinsic apoptotic signaling pathway in response to DNA damage extrinsic apoptotic signaling pathway in absence of ligand transcription initiation from RNA polymerase II promoter Unfolded Protein Response negative regulation of mitochondrial membrane potential Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 581 12028 Ensembl ENSG00000087088 ENSMUSG00000003873 UniProt Q07812 Q5ZPJ0 Q07813 RefSeq (mRNA) NM_001291428 NM_001291429 NM_001291430 NM_001291431 NM_004324 NM_138761 NM_138762 NM_138763 NM_138764 NM_007527 RefSeq (protein) NP_001278357 NP_001278358 NP_001278359 NP_001278360 NP_004315 NP_620116 NP_620118 NP_620119 NP_001278358.1 NP_031553 Location (UCSC) Chr 19: 48.95 – 48.96 Mb Chr 7: 45.11 – 45.12 Mb PubMed search [3] [4]
Wikidata
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Apoptosis regulator BAX, also known as bcl-2-like protein 4, is a protein that in humans is encoded by the BAX gene.^[5] BAX is a member of the Bcl-2 gene family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein forms a heterodimer with BCL2, and functions as an apoptotic activator. This protein is reported to interact with, and increase the opening of, the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in membrane potential and the release of cytochrome c. The expression of this gene is regulated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis.^[6]