Atypical antipsychotic
Aripiprazole Pronunciation AIR -ih-PIP -rə-zohl Abilify ə-BIL -if-eye Trade names Abilify, Aristada, others Other names OPC-14597; OPC14597; OPC-31; OPC31; RDC-3317 AHFS /Drugs.com Monograph MedlinePlus a603012 License data
Pregnancy category Routes of administration By mouth , intramuscular Drug class Atypical antipsychotic ATC code Legal status
Bioavailability 87%[ 4] [ 6] [ 7] Protein binding >99%[ 4] [ 6] [ 7] Metabolism Liver (mostly via CYP3A4 and 2D6 [ 4] [ 6] [ 7] )Elimination half-life 75 hours (active metabolite is 94 hours)[ 4] [ 6] [ 7] Excretion Kidney (27%; <1% unchanged)feces (60%; 18% unchanged)[ 4] [ 6] [ 7]
7-{4-[4-(2,3-Dichlorophenyl)piperazin-1-yl]butoxy}-3,4-dihydroquinolin-2(1H )-one
CAS Number PubChem CID IUPHAR/BPS DrugBank ChemSpider UNII KEGG ChEBI ChEMBL CompTox Dashboard (EPA ) ECHA InfoCard 100.112.532 Formula C 23 H 27 Cl 2 N 3 O 2 Molar mass 448.39 g·mol−1 3D model (JSmol )
Clc4cccc(N3CCN(CCCCOc2ccc1c(NC(=O)CC1)c2)CC3)c4Cl
InChI=1S/C23H27Cl2N3O2/c24-19-4-3-5-21(23(19)25)28-13-11-27(12-14-28)10-1-2-15-30-18-8-6-17-7-9-22(29)26-20(17)16-18/h3-6,8,16H,1-2,7,9-15H2,(H,26,29)
Y Key:CEUORZQYGODEFX-UHFFFAOYSA-N
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Aribit (Aripiprazole) tablets
Aripiprazole , sold under the brand names Abilify and Aristada , among others, is an atypical antipsychotic .[ 8] It is primarily used in the treatment of schizophrenia and bipolar disorder ;[ 8] other uses include as an add-on treatment in major depressive disorder and obsessive–compulsive disorder (OCD), tic disorders , and irritability associated with autism .[ 8] Aripiprazole is taken by mouth or via injection into a muscle .[ 8] A Cochrane review found low-quality evidence of effectiveness in treating schizophrenia.[ 9]
Common side effects include restlessness , insomnia , transient weight gain , nausea , vomiting , constipation , dizziness , and mild sedation .[ 8] Serious side effects may include neuroleptic malignant syndrome , tardive dyskinesia , and anaphylaxis .[ 8] It is not recommended for older people with dementia -related psychosis due to an increased risk of death.[ 8] In pregnancy , there is evidence of possible harm to the fetus.[ 8] [ 10] It is not recommended in women who are breastfeeding .[ 8] It has not been very well studied in people less than 18 years old.[ 8]
Aripiprazole was approved for medical use in the United States in 2002.[ 8] It is available as a generic medication .[ 11] In 2022, it was the 106th most commonly prescribed medication in the United States, with more than 6 million prescriptions.[ 12] [ 13] It is on the World Health Organization's List of Essential Medicines .[ 14]
^ "Aripiprazole Use During Pregnancy" . Drugs.com . 22 August 2019. Archived from the original on 12 November 2020. Retrieved 7 February 2020 .
^ "FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)" . nctr-crs.fda.gov . FDA . Retrieved 22 October 2023 .
^ Anvisa (31 March 2023). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 4 April 2023). Archived from the original on 3 August 2023. Retrieved 16 August 2023 .
^ a b c d e f Cite error: The named reference Abilify FDA label
was invoked but never defined (see the help page ).
^ "Abilify EPAR" . European Medicines Agency . 4 June 2004. Archived from the original on 15 April 2024. Retrieved 4 July 2024 .
^ a b c d e "Abilify Tablets, Orodispersible Tablets, Oral Solution – Summary of Product Characteristics (SPC)" . electronic Medicines Compendium . Otsuka Pharmaceuticals (UK) Ltd. 20 September 2013. Archived from the original on 4 March 2016. Retrieved 22 October 2013 .
^ a b c d e "ANNEX I SUMMARY OF PRODUCT CHARACTERISTICS" (PDF) . European Medicines Agency . Otsuka Pharmaceutical Europe Ltd. Archived from the original (PDF) on 23 October 2013. Retrieved 22 October 2013 .
^ a b c d e f g h i j k "Aripiprazole, ARIPiprazole Lauroxil Monograph for Professionals" . Drugs.com . American Society of Health-System Pharmacists. Archived from the original on 1 October 2020. Retrieved 26 February 2019 .
^ Belgamwar RB, El-Sayeh HG (August 2011). "Aripiprazole versus placebo for schizophrenia". The Cochrane Database of Systematic Reviews (8): CD006622. doi :10.1002/14651858.CD006622.pub2 . PMID 21833956 .
^ "Prescribing medicines in pregnancy database" . Australian Government . 3 March 2014. Archived from the original on 8 April 2014. Retrieved 22 April 2014 .
^ British national formulary: BNF 76 (76th ed.). Pharmaceutical Press. 2018. p. 392. ISBN 978-0-85711-338-2 .
^ "The Top 300 of 2022" . ClinCalc . Archived from the original on 30 August 2024. Retrieved 30 August 2024 .
^ "Aripiprazole Drug Usage Statistics, United States, 2013 - 2022" . ClinCalc . Retrieved 30 August 2024 .
^ World Health Organization (2023). The selection and use of essential medicines 2023: web annex A: World Health Organization model list of essential medicines: 23rd list (2023) . Geneva: World Health Organization. hdl :10665/371090 . WHO/MHP/HPS/EML/2023.02.