Family of proteins
Arrestins (abbreviated Arr) are a small family of proteins important for regulating signal transduction at G protein-coupled receptors.[2][3]
Arrestins were first discovered as a part of a conserved two-step mechanism for regulating the activity of G protein-coupled receptors (GPCRs) in the visual rhodopsin system by Hermann Kühn, Scott Hall, and Ursula Wilden[4] and in the β-adrenergic system by Martin J. Lohse and co-workers.[5][6]
- ^ PDB: 1CF1; Hirsch JA, Schubert C, Gurevich VV, Sigler PB (April 1999). "The 2.8 A crystal structure of visual arrestin: a model for arrestin's regulation". Cell. 97 (2): 257–69. doi:10.1016/S0092-8674(00)80735-7. PMID 10219246. S2CID 17124300.
- ^ Moore CA, Milano SK, Benovic JL (2007). "Regulation of receptor trafficking by GRKs and arrestins". Annual Review of Physiology. 69: 451–82. doi:10.1146/annurev.physiol.69.022405.154712. PMID 17037978.
- ^ Lefkowitz RJ, Shenoy SK (April 2005). "Transduction of receptor signals by beta-arrestins". Science. 308 (5721): 512–7. Bibcode:2005Sci...308..512L. doi:10.1126/science.1109237. PMID 15845844. S2CID 26931077.
- ^ Wilden U, Hall SW, Kühn H (March 1986). "Phosphodiesterase activation by photoexcited rhodopsin is quenched when rhodopsin is phosphorylated and binds the intrinsic 48-kDa protein of rod outer segments". Proceedings of the National Academy of Sciences of the United States of America. 83 (5): 1174–8. Bibcode:1986PNAS...83.1174W. doi:10.1073/pnas.83.5.1174. PMC 323037. PMID 3006038.
- ^ Lohse MJ, Benovic JL, Codina J, Caron MG, Lefkowitz RJ (June 1990). "beta-Arrestin: a protein that regulates beta-adrenergic receptor function". Science. 248 (4962): 1547–50. Bibcode:1990Sci...248.1547L. doi:10.1126/science.2163110. PMID 2163110.
- ^ Gurevich VV, Gurevich EV (June 2006). "The structural basis of arrestin-mediated regulation of G-protein-coupled receptors". Pharmacology & Therapeutics. 110 (3): 465–502. doi:10.1016/j.pharmthera.2005.09.008. PMC 2562282. PMID 16460808.
