Arrestin beta 1

ARRB1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2IV8
Identifiers
Aliases	ARRB1, ARB1, ARR1, Arrestin beta 1
External IDs	OMIM: 107940; MGI: 99473; HomoloGene: 2981; GeneCards: ARRB1; OMA:ARRB1 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	75,351,705 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	99,255,978 bp
RNA expression pattern
	Top expressed in
	monocyte; ; granulocyte; ; right lung; ; upper lobe of left lung; ; anterior cingulate cortex; ; sural nerve; ; right frontal lobe; ; prefrontal cortex; ; nucleus accumbens; ; body of stomach;
	Top expressed in
	fetal liver hematopoietic progenitor cell; ; superior frontal gyrus; ; inferior colliculi; ; granulocyte; ; molar; ; tibiofemoral joint; ; superior colliculus; ; dentate gyrus of hippocampal formation granule cell; ; primary visual cortex; ; cerebellar cortex;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	GTPase activator activity; histone acetyltransferase activity; enzyme inhibitor activity; insulin-like growth factor receptor binding; transcription factor binding; mitogen-activated protein kinase kinase binding; clathrin adaptor activity; protein phosphorylated amino acid binding; cysteine-type endopeptidase inhibitor activity involved in apoptotic process; protein binding; AP-2 adaptor complex binding; alpha-1B adrenergic receptor binding; V2 vasopressin receptor binding; phosphoprotein binding; angiotensin receptor binding; ubiquitin protein ligase binding; arrestin family protein binding; signaling receptor binding; enzyme binding; estrogen receptor binding; alpha-1A adrenergic receptor binding; follicle-stimulating hormone receptor binding; transmembrane transporter binding; clathrin binding; G protein-coupled receptor binding;
Cellular component	cytoplasm; cytosol; postsynaptic membrane; membrane; nucleus; cell projection; dendritic spine; heterotrimeric G-protein complex; chromatin; plasma membrane; intracellular anatomical structure; nucleoplasm; clathrin-coated pit; pseudopodium; postsynaptic density; Golgi membrane; lysosomal membrane; basolateral plasma membrane; cytoplasmic vesicle membrane; cytoplasmic vesicle; nuclear body; endosome;
Biological process	positive regulation of Rho protein signal transduction; regulation of G protein-coupled receptor signaling pathway; positive regulation of receptor internalization; transcription by RNA polymerase II; stress fiber assembly; follicle-stimulating hormone signaling pathway; platelet activation; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of GTPase activity; positive regulation of ERK1 and ERK2 cascade; positive regulation of insulin secretion involved in cellular response to glucose stimulus; proteasome-mediated ubiquitin-dependent protein catabolic process; phototransduction; regulation of transcription, DNA-templated; transcription, DNA-templated; positive regulation of peptidyl-serine phosphorylation; negative regulation of interleukin-8 production; protein ubiquitination; protein transport; negative regulation of protein phosphorylation; positive regulation of smooth muscle cell apoptotic process; positive regulation of histone H4 acetylation; positive regulation of protein binding; negative regulation of NF-kappaB transcription factor activity; positive regulation of protein ubiquitination; G protein-coupled receptor internalization; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; endocytosis; negative regulation of interleukin-6 production; positive regulation of histone acetylation; negative regulation of protein ubiquitination; negative regulation of ERK1 and ERK2 cascade; negative regulation of signal transduction; positive regulation of transcription by RNA polymerase II; signal transduction; positive regulation of GTPase activity; apoptotic process; membrane organization; regulation of apoptotic process; ubiquitin-dependent protein catabolic process; negative regulation of Notch signaling pathway; G protein-coupled receptor signaling pathway; positive regulation of protein phosphorylation; positive regulation of cell population proliferation; negative regulation of apoptotic process; negative regulation of neuron apoptotic process; histone acetylation;
	Sources:Amigo / QuickGO
Orthologs
	408
	109689
	ENSG00000137486
	ENSMUSG00000018909
	P49407
	Q8BWG8
	NM_004041; NM_020251
	NM_177231; NM_178220
	NP_004032; NP_064647
	NP_796205; NP_835738
	Wikidata
View/Edit Human	View/Edit Mouse

Arrestin, beta 1, also known as ARRB1, is a protein which in humans is encoded by the ARRB1 gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000137486 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000018909 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Parruti G, Peracchia F, Sallese M, Ambrosini G, Masini M, Rotilio D, De Blasi A (May 1993). "Molecular analysis of human beta-arrestin-1: cloning, tissue distribution, and regulation of expression. Identification of two isoforms generated by alternative splicing". The Journal of Biological Chemistry. 268 (13): 9753–9761. doi:10.1016/S0021-9258(18)98412-7. PMID 8486659.
^ "Entrez Gene: ARRB1 arrestin, beta 1".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000137486 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000018909 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8486659-5] Parruti G, Peracchia F, Sallese M, Ambrosini G, Masini M, Rotilio D, De Blasi A (May 1993). "Molecular analysis of human beta-arrestin-1: cloning, tissue distribution, and regulation of expression. Identification of two isoforms generated by alternative splicing". The Journal of Biological Chemistry. 268 (13): 9753–9761. doi:10.1016/S0021-9258(18)98412-7. PMID 8486659.

[entrez-6] "Entrez Gene: ARRB1 arrestin, beta 1".

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