Artemis (protein)

DCLRE1C
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3W1B, 3W1G, 4HTP
Identifiers
Aliases	DCLRE1C, A-SCID, DCLREC1C, RS-SCID, SCIDA, SNM1C, DNA cross-link repair 1C
External IDs	OMIM: 605988; MGI: 2441769; HomoloGene: 32547; GeneCards: DCLRE1C; OMA:DCLRE1C - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	14,954,432 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	3,465,167 bp
RNA expression pattern
	Top expressed in
	buccal mucosa cell; ; tendon of biceps brachii; ; epithelium of nasopharynx; ; sperm; ; nipple; ; pylorus; ; cardia; ; superior surface of tongue; ; endothelial cell; ; amniotic fluid;
	Top expressed in
	granulocyte; ; tail of embryo; ; zygote; ; genital tubercle; ; morula; ; thymus; ; spermatocyte; ; yolk sac; ; blastocyst; ; embryo;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	5'-3' exonuclease activity; 5'-3' exodeoxyribonuclease activity; damaged DNA binding; single-stranded DNA endodeoxyribonuclease activity; protein binding; nuclease activity; endonuclease activity; exonuclease activity; hydrolase activity;
Cellular component	nonhomologous end joining complex; nucleus; nucleoplasm; Golgi apparatus;
Biological process	response to ionizing radiation; DNA recombination; adaptive immune response; interstrand cross-link repair; protection from non-homologous end joining at telomere; immune system process; chromosome organization; cellular response to DNA damage stimulus; V(D)J recombination; B cell differentiation; double-strand break repair via nonhomologous end joining; telomere maintenance; nucleic acid phosphodiester bond hydrolysis; double-strand break repair; DNA repair;
	Sources:Amigo / QuickGO
Orthologs
	64421
	227525
	ENSG00000152457
	ENSMUSG00000026648
	Q96SD1
	Q8K4J0
NM_001033855; NM_001033857; NM_001033858; NM_001289076; NM_001289077;
	NM_001289078; NM_001289079; NM_022487; NM_001350965; NM_001350966; NM_001350967
NM_001110214; NM_146114; NM_175683; NM_001302674; NM_001302684;
	NM_001362903; NM_001362904
NP_001029027; NP_001029029; NP_001029030; NP_001276005; NP_001276006;
	NP_001276007; NP_001276008; NP_071932; NP_001337894; NP_001337895; NP_001337896
NP_001103684; NP_001289603; NP_001289613; NP_666226; NP_783614;
	NP_001349832; NP_001349833
	Wikidata
View/Edit Human	View/Edit Mouse

Artemis is a protein that in humans is encoded by the DCLRE1C (DNA cross-link repair 1C) gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000152457 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000026648 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Moshous D, Callebaut I, de Chasseval R, Corneo B, Cavazzana-Calvo M, Le Deist F, Tezcan I, Sanal O, Bertrand Y, Philippe N, Fischer A, de Villartay JP (May 2001). "Artemis, a novel DNA double-strand break repair/V(D)J recombination protein, is mutated in human severe combined immune deficiency". Cell. 105 (2): 177–86. doi:10.1016/S0092-8674(01)00309-9. hdl:11655/13789. PMID 11336668. S2CID 12610896.
^ Li L, Drayna D, Hu D, Hayward A, Gahagan S, Pabst H, Cowan MJ (Mar 1998). "The gene for severe combined immunodeficiency disease in Athabascan-speaking Native Americans is located on chromosome 10p". Am. J. Hum. Genet. 62 (1): 136–44. doi:10.1086/301688. PMC 1376812. PMID 9443881.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000152457 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000026648 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11336668-5] Moshous D, Callebaut I, de Chasseval R, Corneo B, Cavazzana-Calvo M, Le Deist F, Tezcan I, Sanal O, Bertrand Y, Philippe N, Fischer A, de Villartay JP (May 2001). "Artemis, a novel DNA double-strand break repair/V(D)J recombination protein, is mutated in human severe combined immune deficiency". Cell. 105 (2): 177–86. doi:10.1016/S0092-8674(01)00309-9. hdl:11655/13789. PMID 11336668. S2CID 12610896.

[pmid9443881-6] Li L, Drayna D, Hu D, Hayward A, Gahagan S, Pabst H, Cowan MJ (Mar 1998). "The gene for severe combined immunodeficiency disease in Athabascan-speaking Native Americans is located on chromosome 10p". Am. J. Hum. Genet. 62 (1): 136–44. doi:10.1086/301688. PMC 1376812. PMID 9443881.

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