Asboe-Hansen sign

The Asboe-Hansen sign (also known as "indirect Nikolsky sign'"[1] or "Nikolsky II sign"[1]) refers to the extension of a large blister to adjacent unblistered skin when pressure is put on the top of it.[2][3] It is seen along with Nikolsky's sign, both used to assess the severity of some blistering diseases such as pemphigus vulgaris and severe bullous drug reactions.[4]

This sign is named for the Danish physician Gustav Asboe-Hansen (1917–1989), who first described it in 1960.[5]

It is considered an indirect diagnostic tool in toxic epidermal necrolysis (TEN).[definition needed]

  1. ^ a b Rapini, Ronald P.; Bolognia, Jean L.; Jorizzo, Joseph L. (2007). Dermatology: 2-Volume Set. St. Louis: Mosby. ISBN 1-4160-2999-0.
  2. ^ James, William; Berger, Timothy; Elston, Dirk (2005) Andrews' Diseases of the Skin: Clinical Dermatology (10th ed.). Saunders. Page 16. ISBN 0-7216-2921-0.
  3. ^ Jonkman, Marcel F.; Horváth, Barbara (2022). "2. Dermatological examination of bullous diseases". In Horváth, Barbara (ed.). Autoimmune Bullous Diseases (2nd ed.). Switzerland: Springer. p. 13. ISBN 978-3-030-91557-5.
  4. ^ James, William D.; Elston, Dirk; Treat, James R.; Rosenbach, Misha A.; Neuhaus, Isaac (2020). "2. Cutaneous signs and diagnosis". Andrews' Diseases of the Skin: Clinical Dermatology (13th ed.). Edinburgh: Elsevier. p. 13. ISBN 978-0-323-54753-6.
  5. ^ Freiman, Anatoli; Kalia, Sunil; O'Brien, Elizabeth A. (July 2006). "Dermatologic Signs". Journal of Cutaneous Medicine and Surgery. 10 (4): 175–182. doi:10.2310/7750.2006.00042.