| Company type | Subsidiary |
|---|---|
| Industry | Pharmaceuticals |
| Founded | 1999 |
| Headquarters | European Corporate and Research headquarters in Cambridge, UK (Astex Therapeutics Limited) US Corporate and Clinical Development headquarters in Pleasanton, California, USA (Astex Pharmaceuticals Inc.) |
Key people | Harren Jhoti (President and CEO) David Rees (Chief Scientific Officer, Astex Therapeutics Limited) Martin Buckland (President and Chief Corporate Officer, Astex Pharmaceuticals Inc.) Harold N. Keer (Chief Medical Officer, Astex Pharmaceuticals Inc.) |
| Products | Therapeutics for oncology and CNS disorders |
| Revenue | not available |
| Parent | Otsuka Pharmaceutical  |
| Website | astx |
Astex Pharmaceuticals ("Astex") is a biotechnology company focused on the discovery and development of drugs in oncology and diseases of the central nervous system. Astex was founded in 1999 by Sir Tom Blundell,[1][2] Chris Abell & Harren Jhoti,[3] and is located in Cambridge, England.[4][5][6][7][8]
Astex is part of the Otsuka group of companies and is a wholly-owned subsidiary of Otsuka Pharmaceutical Co. Ltd, headquartered in Tokyo, Japan.[9]
- ^ Tom Blundell: Director Archived January 1, 2015, at the Wayback Machine on OpenCorporates
- ^ Congreve, M; Murray, C. W.; Blundell, T. L. (2005). "Structural biology and drug discovery". Drug Discovery Today. 10 (13): 895–907. doi:10.1016/S1359-6446(05)03484-7. PMID 15993809.
- ^ Williams, P. A.; Cosme, J; Vinkovic, D. M.; Ward, A; Angove, H. C.; Day, P. J.; Vonrhein, C; Tickle, I. J.; Jhoti, H (2004). "Crystal structures of human cytochrome P450 3A4 bound to metyrapone and progesterone". Science. 305 (5684): 683–6. Bibcode:2004Sci...305..683W. doi:10.1126/science.1099736. PMID 15256616. S2CID 23149841.
- ^ Repasky, M. P.; Murphy, R. B.; Banks, J. L.; Greenwood, J. R.; Tubert-Brohman, I; Bhat, S; Friesner, R. A. (2012). "Docking performance of the glide program as evaluated on the Astex and DUD datasets: A complete set of glide SP results and selected results for a new scoring function integrating Water Map and glide". Journal of Computer-Aided Molecular Design. 26 (6): 787–99. Bibcode:2012JCAMD..26..787R. doi:10.1007/s10822-012-9575-9. PMID 22576241. S2CID 34803972.
- ^ Novikov, F. N.; Stroylov, V. S.; Zeifman, A. A.; Stroganov, O. V.; Kulkov, V; Chilov, G. G. (2012). "Lead Finder docking and virtual screening evaluation with Astex and DUD test sets". Journal of Computer-Aided Molecular Design. 26 (6): 725–35. Bibcode:2012JCAMD..26..725N. doi:10.1007/s10822-012-9549-y. PMID 22569592. S2CID 22123557.
- ^ Wolfson, W (2006). "Fragmentary solutions. Astex therapeutics puts the pieces together". Chemistry & Biology. 13 (8): 799–801. doi:10.1016/j.chembiol.2006.08.003. PMID 16931326.
- ^ Mountain, V (2003). "Astex, Structural Genomix, and Syrrx. I can see clearly now: Structural biology and drug discovery". Chemistry & Biology. 10 (2): 95–8. doi:10.1016/s1074-5521(03)00030-9. PMID 12618177.
- ^ Carr, R. A.; Congreve, M; Murray, C. W.; Rees, D. C. (2005). "Fragment-based lead discovery: Leads by design". Drug Discovery Today. 10 (14): 987–92. doi:10.1016/S1359-6446(05)03511-7. PMID 16023057.
- ^ "Japan's Otsuka to buy Astex Pharma for about $900 million: Nikkei". Reuters. 4 September 2013. Retrieved 14 April 2021.