Atiprimod

Atiprimod
Ball-and-stick model of the atiprimod molecule
Clinical data
ATC code
  • none
Identifiers
  • 3-(8,8-dipropyl-3-azaspiro[4.5]decan-3-yl)-N,N- diethylpropan-1-amine
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC22H44N2
Molar mass336.608 g·mol−1
3D model (JSmol)
  • N(CC)(CC)CCCN2CCC1(CCC(CC1)(CCC)CCC)C2
  • InChI=1S/C22H44N2/c1-5-10-21(11-6-2)12-14-22(15-13-21)16-19-24(20-22)18-9-17-23(7-3)8-4/h5-20H2,1-4H3 checkY
  • Key:SERHTTSLBVGRBY-UHFFFAOYSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Atiprimod (INN, codenamed SK&F106615) is a substance being studied in the treatment of certain multiple myelomas and other advanced cancers. It may block the growth of tumors and the growth of blood vessels from surrounding tissue to the tumor. This drug is also being researched as a potential treatment for various autoimmune diseases.

It was first developed by GlaxoSmithKline as a potential treatment for rheumatoid arthritis.[1][2][3]

It also had application in the treatment of hyperlipidæmia:[4]

This compound has also been shown to kill mantle cell lymphoma cells in vitro.[5]

  1. ^ Jacobs GS (Spring 2004). "Atiprimod: A New Drug Candidate in Early-Stage Development for Myeloma". Myeloma Today. 5 (10). International Myeloma Foundation. Archived from the original on 2011-07-18. Retrieved 2010-09-30.
  2. ^ Badger, A. M., Schwartz, D. A., Picker, D. H., Dorman, J. W., Bradley, F. C., Cheeseman, E. N., DiMartino, M. J., Hanna, N., Mirabelli, C. K. (November 1990). "Antiarthritic and supressor cell inducing activity of azaspiranes: structure-function relationships of a novel class of immunomodulatory agents". Journal of Medicinal Chemistry. 33 (11): 2963–2970. doi:10.1021/jm00173a010.
  3. ^ US4963557 idem Alison M. Badger, WO1989002889 (to Callisto Pharmaceuticals Inc).
  4. ^ Alison Mary Badger, WO1994025024 (to SmithKline Beecham Corp).
  5. ^ Wang M, Zhang L, Han X, Yang J, Qian J, Hong S, et al. (June 2007). "Atiprimod inhibits the growth of mantle cell lymphoma in vitro and in vivo and induces apoptosis via activating the mitochondrial pathways". Blood. 109 (12): 5455–5462. doi:10.1182/blood-2006-12-063958. PMID 17317853.