Atropine/diphenoxylate

Atropine/diphenoxylate
Combination of
DiphenoxylateMu opiate receptor agonist
AtropineMuscarinic acetylcholine receptors antagonist
Clinical data
Trade namesLomotil
AHFS/Drugs.comProfessional Drug Facts
License data
Pregnancy
category
  • AU: C
Routes of
administration		By mouth
ATC code
  • None
Legal status
Legal status
Identifiers
CAS Number
PubChem CID
ChemSpider
  • none
KEGG
ChEBI
  (verify)

Diphenoxylate/atropine, also known as co-phenotrope, is a combination of the medications diphenoxylate and atropine, used to treat diarrhea.[2][3] It should not be used in those in whom Clostridioides difficile infection is a concern.[4] It is taken by mouth.[2] Onset is typically within an hour.[5]

Side effects may include abdominal pain, angioedema, glaucoma, heart problems, feeling tired, dry mouth, and trouble seeing.[2] It is unclear if use in pregnancy is safe and use when breastfeeding may result in side effects in the baby.[6] It works by decreasing contractions of the bowel.[2]

The combination was approved for medical use in the United States in 1960.[5] It is available as a generic medication.[2] In 2021, it was the 293rd most commonly prescribed medication in the United States, with more than 600,000 prescriptions.[7][8] It is sold under the brand name Lomotil among others.[2] The medication is in Schedule V in the United States.[4]

  1. ^ "Lomotil- diphenoxylate hydrochloride and atropine sulfate tablet". DailyMed. U.S. National Library of Medicine. 25 October 2021. Retrieved 20 February 2022.
  2. ^ a b c d e f British National Formulary (76th ed.). Pharmaceutical Press. 2018. p. 66. ISBN 9780857113382.
  3. ^ Jain M, Wylie WP (June 2021). "Diphenoxylate and Atropine". StatPerls. Treasure Island (FL): StatPearls Publishing. PMID 32644726.
  4. ^ a b "Diphenoxylate hydrochloride and atropine sulfate solution". DailyMed. U.S. National Library of Medicine. Retrieved 22 March 2019.
  5. ^ a b "Diphenoxylate and Atropine (Professional Patient Advice)". Drugs.com. Retrieved 22 March 2019.
  6. ^ "Atropine / diphenoxylate Pregnancy and Breastfeeding Warnings". Drugs.com. Retrieved 3 March 2019.
  7. ^ "The Top 300 of 2021". ClinCalc. Archived from the original on 15 January 2024. Retrieved 14 January 2024.
  8. ^ "Atropine; Diphenoxylate - Drug Usage Statistics". ClinCalc. Retrieved 14 January 2024.