Autophagy protein 5

ATG5
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4GDK, 4GDL, 4NAW, 4TQ0, 4TQ1, 5D7G
Identifiers
Aliases	ATG5, APG5, APG5-LIKE, APG5L, ASP, hAPG5, autophagy related 5, SCAR25
External IDs	OMIM: 604261; MGI: 1277186; HomoloGene: 3566; GeneCards: ATG5; OMA:ATG5 - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6q21 Start 106,045,423 bp[1] End 106,325,791 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10 B2|10 23.24 cM Start 44,144,354 bp[2] End 44,240,287 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gonad mucosa of colon mucosa of sigmoid colon Achilles tendon jejunal mucosa endothelial cell oocyte rectum islet of Langerhans testicle Top expressed in primary oocyte secondary oocyte zygote facial motor nucleus lacrimal gland epithelium of stomach left lobe of liver Rostral migratory stream seminal vesicula transitional epithelium of urinary bladder More reference expression data BioGPS More reference expression data
Gene ontology Molecular function Atg8 ligase activity protein binding Cellular component cytoplasm phagophore assembly site membrane cytosol phagocytic vesicle membrane membrane Atg12-Atg5-Atg16 complex autophagosome axoneme mitochondria associated membranes Biological process immune system process negative regulation of cell death C-terminal protein lipidation autophagy of nucleus cellular response to nitrogen starvation apoptotic process autophagosome assembly autophagy of mitochondrion blood vessel remodeling cellular response to starvation response to fungus macroautophagy cellular homeostasis antigen processing and presentation of endogenous antigen negative regulation of protein ubiquitination aggrephagy negative stranded viral RNA replication vasodilation negative regulation of apoptotic process post-translational protein modification negative thymic T cell selection otolith development negative regulation of phagocytosis regulation of release of sequestered calcium ion into cytosol ventricular cardiac muscle cell development heart contraction protein lipidation involved in autophagosome assembly positive regulation of mucus secretion cellular response to nitrosative stress regulation of cilium assembly regulation of reactive oxygen species metabolic process negative regulation of reactive oxygen species metabolic process negative regulation of histone H4-K16 acetylation autophagy Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9474 11793 Ensembl ENSG00000057663 ENSMUSG00000038160 UniProt Q9H1Y0 Q99J83 RefSeq (mRNA) NM_001286106 NM_001286107 NM_001286108 NM_001286111 NM_004849 NM_053069 NM_001314013 NM_001358596 RefSeq (protein) NP_001273035 NP_001273036 NP_001273037 NP_001273040 NP_004840 NP_001300942 NP_444299 NP_001345525 Location (UCSC) Chr 6: 106.05 – 106.33 Mb Chr 10: 44.14 – 44.24 Mb PubMed search [3] [4]
Wikidata
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Autophagy protein 5 (ATG5) is a protein that, in humans, is encoded by the ATG5 gene located on chromosome 6. It is an E3 ubi autophagic cell death. ATG5 is a key protein involved in the extension of the phagophoric membrane in autophagic vesicles. It is activated by ATG7 and forms a complex with ATG12 and ATG16L1. This complex is necessary for LC3-I (microtubule-associated proteins 1A/1B light chain 3B) conjugation to PE (phosphatidylethanolamine) to form LC3-II (LC3-phosphatidylethanolamine conjugate). ATG5 can also act as a pro-apoptotic molecule targeted to the mitochondria. Under low levels of DNA damage, ATG5 can translocate to the nucleus and interact with survivin.

ATG5 is known to be regulated via various stress induced transcription factors and protein kinases.