Azaperone

Not to be confused with azapirone.

Azaperone
Clinical data
AHFS/Drugs.comInternational Drug Names
Routes of
administration		IM
ATCvet code
Pharmacokinetic data
MetabolismHepatic
Elimination half-life4 hours
Identifiers
  • 1-(4-fluorophenyl)-4-[4-(pyridin-2-yl)piperazin-1-yl]butan-1-one
CAS Number
PubChem CID
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.015.197 Edit this at Wikidata
Chemical and physical data
FormulaC19H22FN3O
Molar mass327.403 g·mol−1
3D model (JSmol)
Melting point90 to 95 °C (194 to 203 °F)
  • Fc1ccc(cc1)C(=O)CCCN3CCN(c2ncccc2)CC3
  • InChI=1S/C19H22FN3O/c20-17-8-6-16(7-9-17)18(24)4-3-11-22-12-14-23(15-13-22)19-5-1-2-10-21-19/h1-2,5-10H,3-4,11-15H2 checkY
  • Key:XTKDAFGWCDAMPY-UHFFFAOYSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Azaperone is a pyridinylpiperazine and butyrophenone neuroleptic drug with sedative and antiemetic effects, which is used mainly as a tranquilizer in veterinary medicine.[1] It is uncommonly used in humans as an antipsychotic drug.

Azaperone acts primarily as a dopamine antagonist but also has some antihistaminic and anticholinergic properties as seen with similar drugs such as haloperidol. Azaperone may cause hypotension and while it has minimal effects on respiration in pigs, high doses in humans can cause respiratory depression.

  1. ^ Posner LP, Burns P (2013). "Sedative agents: tranquilizers, alpha-2 agonists, and related agents. Veterinary pharmacology and therapeutics. 2009:.". In Riviere JE, Papich MG (eds.). Veterinary Pharmacology and Therapeutics (9th ed.). Somerset: Wiley. pp. 337–380 (366). ISBN 978-1-118-68590-7.