Azilsartan

Azilsartan
Clinical data
Trade namesEdarbi, Azilva
Other namesTAK-536, TAK-491
AHFS/Drugs.comMonograph
MedlinePlusa611028
License data
Routes of
administration		By mouth
ATC code
Legal status
Legal status
Pharmacokinetic data
Bioavailability60%
MetabolismCYP2C9
Elimination half-life11 hrs
Excretion55% feces, 42% urine
Identifiers
  • 2-Ethoxy-1-{[2'-(5-oxo-2,5-dihydro-1,2,4-oxadiazol-3-yl)-4-biphenylyl]methyl}-1H-benzimidazole-7-carboxylic acid
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.235.975 Edit this at Wikidata
Chemical and physical data
FormulaC25H20N4O5
Molar mass456.458 g·mol−1
3D model (JSmol)
  • CCOC1=NC2=CC=CC(=C2N1CC3=CC=C(C=C3)C4=CC=CC=C4C5=NOC(=O)N5)C(=O)O
  • InChI=InChI=1S/C25H20N4O5/c1-2-33-24-26-20-9-5-8-19(23(30)31)21(20)29(24)14-15-10-12-16(13-11-15)17-6-3-4-7-18(17)22-27-25(32)34-28-22/h3-13H,2,14H2,1H3,(H,30,31)(H,27,28,32) ☒N
  • Key:KGSXMPPBFPAXLY-UHFFFAOYSA-N ☒N

  • as medoxomil: InChI=1S/C30H24N4O8 /c1-3-38-28-31-23-10-6-9-22(27(35)39-16-24-17(2)40-30(37)41-24)25(23)34(28)15-18-11-13-19(14-12-18)20-7-4-5-8-21(20)26-32-29(36)42-33-26/h4-14H,3,15-16H2,1-2H3,(H,32,33,36)
  • Key:QJFSABGVXDWMIW-UHFFFAOYSA-N
 ☒NcheckY (what is this?)  (verify)

Azilsartan, sold under the brand name Edarbi among others, is used for the treatment of hypertension.[2][3][4] It is used as the prodrug azilsartan medoxomil, is an angiotensin II receptor antagonist,[5] and was developed by Takeda.

The most common adverse reaction in adults is diarrhea.[2]

It is available as a generic medication.[6] It is also sold as a combination drug with chlortalidone under the brand name Edarbyclor.[7]

  1. ^ "Product monograph brand safety updates". Health Canada. February 2024. Retrieved 24 March 2024.
  2. ^ a b "Edarbi- azilsartan kamedoxomil tablet". DailyMed. 26 July 2019. Retrieved 9 March 2020.
  3. ^ Hardin MD, Jacobs TF (July 2021). "Azilsartan". StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing. PMID 30860708.
  4. ^ Pradhan A, Tiwari A, Sethi R (2019). "Azilsartan: Current Evidence and Perspectives in Management of Hypertension". International Journal of Hypertension. 2019: 1824621. doi:10.1155/2019/1824621. PMC 6925743. PMID 31885897.
  5. ^ "Edarbi EPAR". European Medicines Agency (EMA). 18 May 2018. Retrieved 9 March 2020.
  6. ^ "2022 First Generic Drug Approvals". U.S. Food and Drug Administration (FDA). 3 March 2023. Archived from the original on 30 June 2023. Retrieved 30 June 2023.
  7. ^ "Drug Approval Package:Edarbyclor (azilsartan medoxomil and chlorthalidone) NDA #202331". U.S. Food and Drug Administration (FDA). 16 August 2012. Retrieved 11 March 2020.