Azimilide

This article may be too technical for most readers to understand. Please help improve it to make it understandable to non-experts, without removing the technical details. (April 2021) (Learn how and when to remove this message)

Azimilide

Clinical data
ATC code	none
Identifiers
IUPAC name 1-({(E)-[5-(4-chlorophenyl)furan-2-yl]methylidene}amino)-3-[4-(4-methylpiperazin-1-yl)butyl]imidazolidine-2,4-dione
CAS Number	149908-53-2 N
PubChem CID	9571004
IUPHAR/BPS	2588
ChemSpider	7845470 Y
UNII	74QU6P2934
ChEMBL	ChEMBL123558 Y
CompTox Dashboard (EPA)	DTXSID10869988
Chemical and physical data
Formula	C23H28ClN5O3
Molar mass	457.96 g·mol−1
3D model (JSmol)	Interactive image
SMILES Clc4ccc(c3oc(\C=N\N1C(=O)N(C(=O)C1)CCCCN2CCN(C)CC2)cc3)cc4
InChI InChI=1S/C23H28ClN5O3/c1-26-12-14-27(15-13-26)10-2-3-11-28-22(30)17-29(23(28)31)25-16-20-8-9-21(32-20)18-4-6-19(24)7-5-18/h4-9,16H,2-3,10-15,17H2,1H3/b25-16+ Y Key:MREBEPTUUMTTIA-PCLIKHOPSA-N Y
NY (what is this?)  (verify)

Azimilide is a class ΙΙΙ antiarrhythmic drug (used to control abnormal heart rhythms). The agents from this heterogeneous group have an effect on the repolarization, they prolong the duration of the action potential and the refractory period. Also they slow down the spontaneous discharge frequency of automatic pacemakers by depressing the slope of diastolic depolarization. They shift the threshold towards zero or hyperpolarize the membrane potential. Although each agent has its own properties and will have thus a different function.