Protein-coding gene in the species Homo sapiens
B-cell maturation antigen (BCMA or BCM ), also known as tumor necrosis factor receptor superfamily member 17 (TNFRSF17 ), is a protein that in humans is encoded by the TNFRSF17 gene .
TNFRSF17 is a cell surface receptor of the TNF receptor superfamily which recognizes B-cell activating factor (BAFF).[ 5] [ 6] [ 7]
Serum B-cell maturation antigen (sBCMA) is the cleaved form of BCMA, found at low levels in the serum of normal patients and generally elevated in patients with multiple myeloma (MM).[ 8]
^ a b c GRCh38: Ensembl release 89: ENSG00000048462 – Ensembl , May 2017
^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022496 – Ensembl , May 2017
^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Laâbi Y, Gras MP, Carbonnel F, Brouet JC, Berger R, Larsen CJ, Tsapis A (November 1992). "A new gene, BCM, on chromosome 16 is fused to the interleukin 2 gene by a t(4;16)(q26;p13) translocation in a malignant T cell lymphoma" . The EMBO Journal . 11 (11): 3897–3904. doi :10.1002/j.1460-2075.1992.tb05482.x . PMC 556899 . PMID 1396583 .
^ Laabi Y, Gras MP, Brouet JC, Berger R, Larsen CJ, Tsapis A (April 1994). "The BCMA gene, preferentially expressed during B lymphoid maturation, is bidirectionally transcribed" . Nucleic Acids Research . 22 (7): 1147–1154. doi :10.1093/nar/22.7.1147 . PMC 523635 . PMID 8165126 .
^ "Entrez Gene: TNFRSF17 tumor necrosis factor receptor superfamily, member 17" .
^ Maglione PJ, Ko HM, Tokuyama M, Gyimesi G, Soof C, Li M, et al. (January 2020). "Serum B-Cell Maturation Antigen (BCMA) Levels Differentiate Primary Antibody Deficiencies" . The Journal of Allergy and Clinical Immunology. In Practice . 8 (1): 283–291.e1. doi :10.1016/j.jaip.2019.08.012 . PMC 6980522 . PMID 31430592 .