B3GALT4

B3GALT4
Identifiers
Aliases	B3GALT4, BETA3GALT4, GALT2, GALT4, beta-1,3-galactosyltransferase 4
External IDs	OMIM: 603095; MGI: 1859517; HomoloGene: 2805; GeneCards: B3GALT4; OMA:B3GALT4 - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p21.32 Start 33,277,123 bp[1] End 33,284,832 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17|17 B1 Start 34,168,883 bp[2] End 34,170,462 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of transverse colon granulocyte left testis right testis olfactory zone of nasal mucosa apex of heart Descending thoracic aorta skin of leg ascending aorta monocyte Top expressed in pyloric antrum gastric mucosa seminal vesicula mucous cell of stomach intestinal villus epithelium of stomach otic vesicle crypt of lieberkuhn of small intestine granulocyte lacrimal gland More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity galactosyltransferase activity ganglioside galactosyltransferase activity glycosyltransferase activity UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity acetylgalactosaminyltransferase activity Cellular component integral component of membrane Golgi membrane Golgi apparatus membrane endoplasmic reticulum Biological process ganglioside biosynthetic process protein glycosylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8705 54218 Ensembl ENSG00000236802 ENSG00000235155 ENSG00000226936 ENSG00000206285 ENSG00000235863 n/a ENSMUSG00000067370 UniProt O96024 Q9Z0F0 RefSeq (mRNA) NM_003782 NM_019420 RefSeq (protein) NP_003773 NP_062293 Location (UCSC) Chr 6: 33.28 – 33.28 Mb Chr 17: 34.17 – 34.17 Mb PubMed search [3] [4]
Wikidata
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Beta-1,3-galactosyltransferase 4 is an enzyme that in humans is encoded by the B3GALT4 gene.^[5][6]

This gene is a member of the beta-1,3-galactosyltransferase (beta3GalT) gene family. This family encodes type II membrane-bound glycoproteins with diverse enzymatic functions using different donor substrates (UDP-galactose and UDP-N-acetylglucosamine) and different acceptor sugars (N-acetylglucosamine, galactose, N-acetylgalactosamine). The beta3GalT genes are distantly related to the Drosophila Brainiac gene and have the protein coding sequence contained in a single exon. The beta3GalT proteins also contain conserved sequences not found in the beta4GalT or alpha3GalT proteins. The carbohydrate chains synthesized by these enzymes are designated as type 1, whereas beta4GalT enzymes synthesize type 2 carbohydrate chains. The ratio of type 1:type 2 chains changes during embryogenesis. By sequence similarity, the beta3GalT genes fall into at least two groups: beta3GalT4 and 4 other beta3GalT genes (beta3GalT1-3, beta3GalT5). This gene is oriented telomere to centromere in close proximity to the ribosomal protein S18 gene. The functionality of the encoded protein is limited to ganglioseries glycolipid biosynthesis.^[6]