B3GAT1

B3GAT1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesB3GAT1, CD57, GLCATP, GLCUATP, HNK1, LEU7, NK-1, NK1, beta-1,3-glucuronyltransferase 1
External IDsOMIM: 151290; MGI: 1924148; HomoloGene: 49551; GeneCards: B3GAT1; OMA:B3GAT1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_018644
NM_054025
NM_001367973

NM_029792
NM_001310766

RefSeq (protein)

NP_061114
NP_473366
NP_001354902

NP_001297695
NP_084068

Location (UCSC)Chr 11: 134.38 – 134.41 MbChr 9: 26.65 – 26.67 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

3-beta-glucuronosyltransferase 1 (B3GAT1) is an enzyme that in humans is encoded by the B3GAT1 gene, whose enzymatic activity creates the CD57 epitope on other cell surface proteins.[5] In immunology, the CD57 antigen (CD stands for cluster of differentiation) is also known as HNK1 (human natural killer-1) or LEU7. It is expressed as a carbohydrate epitope that contains a sulfoglucuronyl residue in several adhesion molecules of the nervous system.[6]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000109956Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000045994Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: B3GAT1 beta-1,3-glucuronyltransferase 1 (glucuronosyltransferase P)".
  6. ^ Mitsumoto Y, Oka S, Sakuma H, Inazawa J, Kawasaki T (April 2000). "Cloning and chromosomal mapping of human glucuronyltransferase involved in biosynthesis of the HNK-1 carbohydrate epitope". Genomics. 65 (2): 166–173. doi:10.1006/geno.2000.6152. PMID 10783264.