B3GNT2

B3GNT2
Identifiers
Aliases	B3GNT2, B3GN-T2, B3GNT, B3GNT-2, B3GNT1, BETA3GNT, BGNT2, BGnT-2, 3-Gn-T1, 3-Gn-T2, beta-1, beta3Gn-T1, beta3Gn-T2, UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2
External IDs	OMIM: 605581; MGI: 1889505; HomoloGene: 4797; GeneCards: B3GNT2; OMA:B3GNT2 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	62,224,731 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	22,810,961 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; visceral pleura; ; epithelium of nasopharynx; ; germinal epithelium; ; lower lobe of lung; ; parietal pleura; ; mucosa of paranasal sinus; ; jejunal mucosa; ; mucosa of sigmoid colon; ; gingival epithelium;
	Top expressed in
	primary oocyte; ; secondary oocyte; ; granulocyte; ; zygote; ; striatum of neuraxis; ; adrenal gland; ; genital tubercle; ; proximal tubule; ; right kidney; ; tail of embryo;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; glycosyltransferase activity; galactosyltransferase activity; N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity; UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity; acetylgalactosaminyltransferase activity; protein binding;
Cellular component	integral component of membrane; Golgi apparatus; membrane; Golgi membrane; endoplasmic reticulum;
Biological process	poly-N-acetyllactosamine biosynthetic process; axon guidance; protein glycosylation; sensory perception of smell; O-glycan processing; keratan sulfate biosynthetic process; cellular response to leukemia inhibitory factor;
	Sources:Amigo / QuickGO
Orthologs
	10678
	53625
	ENSG00000170340
	ENSMUSG00000051650
	Q9NY97
	Q9Z222
	NM_006577; NM_033252; NM_001319075; NM_018554
	NM_001169114; NM_016888
	NP_001306004; NP_006568
	NP_001162585; NP_058584
	Wikidata
View/Edit Human	View/Edit Mouse

UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 is an enzyme that in humans is encoded by the B3GNT2 gene.^[5]^[6]^[7]

This gene encodes a member of the beta-1,3-N-acetylglucosaminyltransferase family. This enzyme is a type II transmembrane protein. It prefers the substrate of lacto-N-neotetraose, and is involved in the biosynthesis of poly-N-acetyllactosamine chains.^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000170340 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000051650 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Zhou D, Dinter A, Gutierrez Gallego R, Kamerling JP, Vliegenthart JF, Berger EG, Hennet T (Mar 1999). "A β-1,3-N-acetylglucosaminyltransferase with poly-N-acetyllactosamine synthase activity is structurally related to β-1,3-galactosyltransferases". Proc Natl Acad Sci U S A. 96 (2): 406–11. Bibcode:1999PNAS...96..406Z. doi:10.1073/pnas.96.2.406. PMC 15149. PMID 9892646.
^ Shiraishi N, Natsume A, Togayachi A, Endo T, Akashima T, Yamada Y, Imai N, Nakagawa S, Koizumi S, Sekine S, Narimatsu H, Sasaki K (May 2001). "Identification and characterization of three novel beta 1,3-N-acetylglucosaminyltransferases structurally related to the beta 1,3-galactosyltransferase family". J Biol Chem. 276 (5): 3498–507. doi:10.1074/jbc.M004800200. PMID 11042166.
^ ^a ^b "Entrez Gene: B3GNT2 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000170340 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000051650 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9892646-5] Zhou D, Dinter A, Gutierrez Gallego R, Kamerling JP, Vliegenthart JF, Berger EG, Hennet T (Mar 1999). "A β-1,3-N-acetylglucosaminyltransferase with poly-N-acetyllactosamine synthase activity is structurally related to β-1,3-galactosyltransferases". Proc Natl Acad Sci U S A. 96 (2): 406–11. Bibcode:1999PNAS...96..406Z. doi:10.1073/pnas.96.2.406. PMC 15149. PMID 9892646.

[pmid11042166-6] Shiraishi N, Natsume A, Togayachi A, Endo T, Akashima T, Yamada Y, Imai N, Nakagawa S, Koizumi S, Sekine S, Narimatsu H, Sasaki K (May 2001). "Identification and characterization of three novel beta 1,3-N-acetylglucosaminyltransferases structurally related to the beta 1,3-galactosyltransferase family". J Biol Chem. 276 (5): 3498–507. doi:10.1074/jbc.M004800200. PMID 11042166.

[entrez-7] "Entrez Gene: B3GNT2 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2".

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