B4GALT2

B4GALT2
Identifiers
Aliases	B4GALT2, B4Gal-T2, B4Gal-T3, beta4Gal-T2, beta-1,4-galactosyltransferase 2
External IDs	OMIM: 604013; MGI: 1858493; HomoloGene: 2804; GeneCards: B4GALT2; OMA:B4GALT2 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p34.1 Start 43,978,943 bp[1] End 43,991,170 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 D1 Start 117,726,457 bp[2] End 117,740,684 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Brodmann area 10 amygdala cingulate gyrus anterior cingulate cortex stromal cell of endometrium right frontal lobe apex of heart ganglionic eminence muscle of thigh gastrocnemius muscle Top expressed in perirhinal cortex entorhinal cortex superior frontal gyrus primary visual cortex ventricular zone neural layer of retina dentate gyrus of hippocampal formation granule cell ovarian follicle yolk sac CA3 field More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity N-acetyllactosamine synthase activity galactosyltransferase activity lactose synthase activity metal ion binding glycosyltransferase activity beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity Cellular component integral component of membrane Golgi cisterna membrane Golgi membrane membrane nucleoplasm Golgi apparatus intracellular membrane-bounded organelle Biological process protein glycosylation keratan sulfate biosynthetic process memory locomotory behavior visual learning cerebellar Purkinje cell layer development brain development carbohydrate metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8704 53418 Ensembl ENSG00000117411 ENSMUSG00000028541 UniProt O60909 Q9Z2Y2 RefSeq (mRNA) NM_030587 NM_001005417 NM_003780 NM_001253381 NM_017377 RefSeq (protein) NP_001005417 NP_003771 NP_085076 NP_001240310 NP_059073 Location (UCSC) Chr 1: 43.98 – 43.99 Mb Chr 4: 117.73 – 117.74 Mb PubMed search [3] [4]
Wikidata
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Beta-1,4-galactosyltransferase 2 is an enzyme that in humans is encoded by the B4GALT2 gene.^[5][6][7]

This gene is one of seven beta-1,4-galactosyltransferase (beta4GalT) genes. They encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose; all transfer galactose in a beta1,4 linkage to similar acceptor sugars: GlcNAc, Glc, and Xyl. Each beta4GalT has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus and which then remains uncleaved to function as a transmembrane anchor. By sequence similarity, the beta4GalTs form four groups: beta4GalT1 and beta4GalT2, beta4GalT3 and beta4GalT4, beta4GalT5 and beta4GalT6, and beta4GalT7. The enzyme encoded by this gene synthesizes N-acetyllactosamine in glycolipids and glycoproteins. Its substrate specificity is affected by alpha-lactalbumin but it is not expressed in lactating mammary tissue. Two transcript variants encoding the same protein have been found for this gene.^[7]