B4GALT4

B4GALT4
Identifiers
Aliases	B4GALT4, B4Gal-T4, beta4Gal-T4, beta-1,4-galactosyltransferase 4
External IDs	OMIM: 604015; MGI: 1928387; HomoloGene: 37848; GeneCards: B4GALT4; OMA:B4GALT4 - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3q13.32 Start 119,211,732 bp[1] End 119,240,946 bp[1]
Gene location (Mouse) Chr. Chromosome 16 (mouse)[2] Band 16|16 B4 Start 38,562,626 bp[2] End 38,589,411 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tendon of biceps brachii beta cell nasal epithelium amniotic fluid epithelium of nasopharynx gallbladder rectum oocyte olfactory zone of nasal mucosa secondary oocyte Top expressed in zygote interventricular septum secondary oocyte primary oocyte genital tubercle seminal vesicula duodenum dentate gyrus of hippocampal formation granule cell tail of embryo yolk sac More reference expression data BioGPS More reference expression data
Gene ontology Molecular function metal ion binding galactosyltransferase activity N-acetyllactosamine synthase activity glycosyltransferase activity transferase activity beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity Cellular component Golgi membrane membrane Golgi cisterna membrane integral component of membrane Golgi apparatus Biological process protein glycosylation keratan sulfate biosynthetic process membrane lipid metabolic process carbohydrate metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8702 56375 Ensembl ENSG00000121578 ENSMUSG00000022793 UniProt O60513 Q9JJ04 RefSeq (mRNA) NM_003778 NM_212543 NM_001285793 NM_019804 RefSeq (protein) NP_003769 NP_997708 NP_001272722 NP_062778 Location (UCSC) Chr 3: 119.21 – 119.24 Mb Chr 16: 38.56 – 38.59 Mb PubMed search [3] [4]
Wikidata
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Beta-1,4-galactosyltransferase 4 is an enzyme that in humans is encoded by the B4GALT4 gene.^[5][6]

This gene is one of seven beta-1,4-galactosyltransferase (beta4GalT) genes. They encode type II membrane-bound glycoproteins that appear to have exclusive specificity for the donor substrate UDP-galactose; all transfer galactose in a beta1,4 linkage to similar acceptor sugars: GlcNAc, Glc, and Xyl. Each beta4GalT has a distinct function in the biosynthesis of different glycoconjugates and saccharide structures. As type II membrane proteins, they have an N-terminal hydrophobic signal sequence that directs the protein to the Golgi apparatus and which then remains uncleaved to function as a transmembrane anchor. By sequence similarity, the beta4GalTs form four groups: beta4GalT1 and beta4GalT2, beta4GalT3 and beta4GalT4, beta4GalT5 and beta4GalT6, and beta4GalT7. The enzyme encoded by this gene appears to mainly play a role in glycolipid biosynthesis. Two alternatively spliced transcript variants have been found for this gene.^[6]