The Bacillus Calmette–Guérin (BCG) vaccine is a vaccine primarily used against tuberculosis (TB).[9] It is named after its inventors Albert Calmette and Camille Guérin.[10][11] In countries where tuberculosis or leprosy is common, one dose is recommended in healthy babies as soon after birth as possible.[9] In areas where tuberculosis is not common, only children at high risk are typically immunized, while suspected cases of tuberculosis are individually tested for and treated.[9] Adults who do not have tuberculosis and have not been previously immunized, but are frequently exposed, may be immunized, as well.[9] BCG also has some effectiveness against Buruli ulcer infection and other nontuberculous mycobacterial infections.[9] Additionally, it is sometimes used as part of the treatment of bladder cancer.[12][13]
Rates of protection against tuberculosis infection vary widely and protection lasts up to 20 years.[9] Among children, it prevents about 20% from getting infected and among those who do get infected, it protects half from developing disease.[14] The vaccine is given by injection into the skin.[9] No evidence shows that additional doses are beneficial.[9]
Serious side effects are rare. Often, redness, swelling, and mild pain occur at the site of injection.[9] A small ulcer may also form with some scarring after healing.[9] Side effects are more common and potentially more severe in those with immunosuppression.[9] Although no harmful effects on the fetus have been observed, there is insufficient evidence about the safety of BCG vaccination during pregnancy and therefore the vaccine is not recommended for use during pregnancy.[9] The vaccine was originally developed from Mycobacterium bovis, which is commonly found in cattle.[9] While it has been weakened, it is still live.[9]
^Cite error: The named reference Japan label was invoked but never defined (see the help page).
^Yamamoto S, Yamamoto T (November 2007). "Historical review of BCG vaccine in Japan". Japanese Journal of Infectious Diseases. 60 (6): 331–336. doi:10.7883/yoken.JJID.2007.331. PMID18032829.
^ abcdefghijklmnoWorld Health Organization (February 2018). "BCG vaccines: WHO position paper – February 2018". Weekly Epidemiological Record. 93 (8): 73–96. hdl:10665/260307. PMID29474026.
^Hawgood BJ (August 2007). "Albert Calmette (1863-1933) and Camille Guérin (1872-1961): the C and G of BCG vaccine". Journal of Medical Biography. 15 (3): 139–146. doi:10.1258/j.jmb.2007.06-15. PMID17641786. S2CID41880560.
^Houghton BB, Chalasani V, Hayne D, Grimison P, Brown CS, Patel MI, et al. (May 2013). "Intravesical chemotherapy plus bacille Calmette-Guérin in non-muscle invasive bladder cancer: a systematic review with meta-analysis". BJU International. 111 (6): 977–983. doi:10.1111/j.1464-410X.2012.11390.x. PMID23253618. S2CID24961108.
^Cite error: The named reference pmid25097193 was invoked but never defined (see the help page).
^World Health Organization (2023). The selection and use of essential medicines 2023: web annex A: World Health Organization model list of essential medicines: 23rd list (2023). Geneva: World Health Organization. hdl:10665/371090. WHO/MHP/HPS/EML/2023.02.
^"BCG Vaccine: WHO position paper". Weekly Epidemiological Record. 4 (79): 27–38. January 2004. hdl:10665/232372.
^Cite error: The named reference pmid 8602127 was invoked but never defined (see the help page).