BCL3

BCL3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1K1A, 1K1B
Identifiers
Aliases	BCL3, BCL4, D19S37, B-cell CLL/lymphoma 3, B cell CLL/lymphoma 3, transcription coactivator, BCL3 transcription coactivator
External IDs	OMIM: 109560; MGI: 88140; HomoloGene: 81738; GeneCards: BCL3; OMA:BCL3 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	44,760,044 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	19,556,695 bp
RNA expression pattern
	Top expressed in
	left uterine tube; ; right lobe of liver; ; upper lobe of left lung; ; gastric mucosa; ; mucosa of transverse colon; ; spleen; ; apex of heart; ; olfactory zone of nasal mucosa; ; left adrenal cortex; ; right lung;
	Top expressed in
	lumbar spinal ganglion; ; granulocyte; ; mesenteric lymph nodes; ; intestinal villus; ; jejunum; ; left lobe of liver; ; duodenum; ; colon; ; ileum; ; ankle joint;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	DNA binding; protein-macromolecule adaptor activity; DNA-binding transcription factor activity; transcription factor binding; protein binding;
Cellular component	cytoplasm; Bcl3-Bcl10 complex; nucleoplasm; perinuclear region of cytoplasm; Bcl3/NF-kappaB2 complex; nucleus; cytosol; plasma membrane; midbody; intracellular membrane-bounded organelle; protein-containing complex;
Biological process	regulation of apoptotic process; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; regulation of DNA binding; regulation of transcription, DNA-templated; T-helper 2 cell differentiation; antimicrobial humoral response; germinal center formation; response to virus; DNA damage response, signal transduction by p53 class mediator; extracellular matrix organization; positive regulation of interferon-gamma production; negative regulation of apoptotic process; spleen development; marginal zone B cell differentiation; positive regulation of translation; transcription, DNA-templated; cellular response to DNA damage stimulus; positive regulation of transcription, DNA-templated; humoral immune response mediated by circulating immunoglobulin; follicular dendritic cell differentiation; defense response to bacterium; T-helper 1 type immune response; negative regulation of transcription, DNA-templated; I-kappaB kinase/NF-kappaB signaling; response to UV-C; maintenance of protein location in nucleus; positive regulation of transcription by RNA polymerase II; defense response to protozoan; negative regulation of receptor signaling pathway via JAK-STAT; regulation of NIK/NF-kappaB signaling;
	Sources:Amigo / QuickGO
Orthologs
	602
	12051
	ENSG00000069399
	ENSMUSG00000053175
	P20749
	Q9Z2F6
	NM_005178
	NM_033601
	NP_005169
	NP_291079
	Wikidata
View/Edit Human	View/Edit Mouse

B-cell lymphoma 3-encoded protein is a protein that in humans is encoded by the BCL3 gene.^[5]^[6]

This gene is a proto-oncogene candidate. It is identified by its translocation into the immunoglobulin alpha-locus in some cases of B-cell leukemia. The protein encoded by this gene contains seven ankyrin repeats, which are most closely related to those found in I kappa B proteins. This protein functions as a transcriptional coactivator that activates through its association with NF-kappa B homodimers. The expression of this gene can be induced by NF-kappa B, which forms a part of the autoregulatory loop that controls the nuclear residence of p50 NF-kappa B.^[7]

Like BCL2, BCL5, BCL6, BCL7A, BCL9, and BCL10, it has clinical significance in lymphoma.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000069399 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000053175 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Wulczyn FG, Naumann M, Scheidereit C (August 1992). "Candidate proto-oncogene bcl-3 encodes a subunit-specific inhibitor of transcription factor NF-kappa B". Nature. 358 (6387): 597–599. Bibcode:1992Natur.358..597W. doi:10.1038/358597a0. PMID 1501714. S2CID 4363340.
^ Ohno H, Takimoto G, McKeithan TW (March 1990). "The candidate proto-oncogene bcl-3 is related to genes implicated in cell lineage determination and cell cycle control". Cell. 60 (6): 991–997. doi:10.1016/0092-8674(90)90347-H. PMID 2180580. S2CID 1919787.
^ "Entrez Gene: BCL3 B-cell CLL/lymphoma 3".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000069399 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000053175 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1501714-5] Wulczyn FG, Naumann M, Scheidereit C (August 1992). "Candidate proto-oncogene bcl-3 encodes a subunit-specific inhibitor of transcription factor NF-kappa B". Nature. 358 (6387): 597–599. Bibcode:1992Natur.358..597W. doi:10.1038/358597a0. PMID 1501714. S2CID 4363340.

[pmid2180580-6] Ohno H, Takimoto G, McKeithan TW (March 1990). "The candidate proto-oncogene bcl-3 is related to genes implicated in cell lineage determination and cell cycle control". Cell. 60 (6): 991–997. doi:10.1016/0092-8674(90)90347-H. PMID 2180580. S2CID 1919787.

[entrez-7] "Entrez Gene: BCL3 B-cell CLL/lymphoma 3".

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